The lung cancer model is an important tool for studying the pathogenesis, drug screening, and therapeutic effects of lung cancer, which helps understand the biological pathogenesis of lung cancer and develop new therapeutic methods. These models include various types such as cell lines, animal models, and computational simulations. In conclusion, the lung cancer model is integral to improving understanding of this complex disease and researching effective interventions to reduce the burden of lung cancer on society ultimately.
Alfa Cytology has unique advantages in lung cancer model services, strong professionalism, high technical capabilities, and perfect customer support to bring you value. With in-depth characterization, clinical annotation, and a library of biologically relevant lung cancer models, we are your best oncology partner.
Comprehensive Model Selection and Customized Solutions
Highly Simulated Models of Human Lung Cancer
Advanced Technology Platform and Professional Team
High Quality Data with Reliable Results
Lung cancer models can be divided into in vivo models and in vitro models, each model has its unique advantages and applications. Alfa Cytology provides lung cancer model development services for new therapies, including but not limited to the following.
In Vivo Models
In vivo models can better reflect the tumor microenvironment, immune response, and pharmacokinetics by simulating the growth and progression of lung cancer in live animals.
In Vitro Models
By growing cells or tissues under laboratory conditions, in vitro models are able to study tumor growth, invasion, and response to potential treatments in a controlled environment, enabling rapid and efficient mechanism studies and drug screening.
Animal Species
Animal models are important for determining the lung cancer therapy. Many animal species have been used as models for lung cancer research. Alfa Cytology offers a variety of animal species models.
Mechanisms Study
Lung cancer models are used to study the molecular and genetic changes that lead to the onset and progression of cancer and are critical to identifying potential therapeutic targets.
Drug Development
Lung cancer models are used to test the effectiveness and safety of new drugs. Predict the effect of treatment in a clinical setting by simulating the human lung cancer environment.
Personalized Therapy
With advances in genomics, lung cancer models can tailor treatments to specific cancer features, thereby improving treatment outcomes.
Screening & Metastasis
Lung cancer models can help discover biomarkers of early diagnosis and understand how lung cancer spreads to other parts of the body.
By combining in vivo and in vitro models, the biological characteristics, drug response, and treatment strategies of lung cancer can be comprehensively and multilevel studied, and the development of lung cancer therapies can be accelerated.
Drug Screening
In vitro models (e.g., cell lines, organoids) are suitable for high-throughput screening, while in vivo models (e.g., PDX, GEMMs) are suitable for validating efficacy.
Mechanism Studies
In vitro models (such as 3D culture and co-culture) are suitable for studying cellular and molecular mechanisms, while in vivo models are suitable for studying tumor microenvironment and systemic effects.
Personalized Medicine
PDX and organoid models can preserve the heterogeneity of patients' tumors and are suitable for the development of personalized treatment programs.
Immunotherapy Research
Immune humanized models and co-culture models are suitable for studying the effects and mechanisms of immunotherapy.
Lung cancer models have a wide range of applications in drug development and disease research and can support multifaceted detection and analysis. Alfa Cytology's lung cancer model can be used for testing in the following areas.
Pharmacodynamics
Pharmacokinetics
Toxicology
Biomarker Discovery and Validation
Metastasis and Invasion Studies
Drug Resistance Mechanism Research
Immunotherapy Evaluation
Tumor Microenvironment Research
Multi-omics Analysis
The development process of lung cancer models varies depending on the type of model (such as humanized animal models, gene-edited mouse models, etc.). Alfa Cytology provides development services for common lung cancer models, including but not limited to the following.
Select Immunodeficient Mice
Use immunodeficient mice (such as NSG, NOG mice) that lack functional T cells, B cells, and NK cells.
Rebuild the Human Immune System
Tumor Transplantation
Transplanting human lung cancer cell lines or patient-derived tumor tissue (PDX) into humanized mice.
Model Validation
Application and Data Analysis
Used to test the efficacy of immunotherapies such as immune checkpoint inhibitors and CAR T cell therapy.
Target Gene Selection
Select driver genes associated with lung cancer (EGFR, KRAS, TP53, ALK, etc.).
Gene Editing Design
Design gene editing strategies using CRISPR/Cas9, TALEN, or Cre-LoxP systems.
Organoid Expansion and Passage
Regular generation expansion of organoids to establish a stable organoid bank.
Model Validation
Verify whether organoids retain features of the original tumor through histological, genomic, and transcriptomic analysis.
Application and Data Analysis
For high-throughput drug screening, personalized medicine, and mechanism research.
Patient Tumor Sample Acquisition
Obtain fresh tumor tissue from surgery or biopsy of lung cancer patients.
Tumor Tissue Treatment
The tumor tissue is cut into small pieces and initial treatment is performed (e.g. removal of necrotic tissue).
Transplantation to Immunodeficient Mice
Transplanting tumor tissue subcutaneously or in situ (e.g. lungs) into immunodeficient mice (e.g. nude mice, NSG mice).
Model Building and Generation
Monitor tumor growth, and when the tumor reaches a certain volume, remove it and transplant it into a new generation of mice to establish a stable PDX model.
Model Validation
Through histological, genomic and transcriptomic analysis, verify that the PDX model retains the pathological and molecular features of the original tumor.
Application and Data Analysis
For personalized drug screening, biomarker discovery, and drug resistance mechanism research.
Patient Tumor Sample Acquisition
Obtain fresh tumor tissue from surgery or biopsy of lung cancer patients.
Tissue Digestion and Culture
Use of specific media (such as those containing growth factors) to promote organoid formation.
Organoid Expansion and Passage
Regular generation expansion of organoids to establish a stable organoid bank.
Model Validation
Verify whether organoids retain features of the original tumor through histological, genomic, and transcriptomic analysis.
Application and Data Analysis
For high-throughput drug screening, personalized medicine, and mechanism research.
How do you ensure the quality of the experimental data?
Alfa Cytology implements strict quality control measures, including the standardization of experimental operations, multiple validation of data, and independent audits, to ensure the reliability and repeatability of data.
How to choose the most suitable animal model?
Our experts will help you choose the most suitable animal model according to your research objectives and experimental needs.
For research use only.
