Oral Cancer

Oral cancer, also known as mouth cancer or oral cavity cancer, refers to a group of malignant tumors that occur in the oral cavity, including the lips, tongue, gums, cheeks, floor of the mouth, and upper palate. Alfa Cytology is a world leader in head and neck cancer research. With our extensive experience and advanced platform, we can provide the best services for oral cancer.

Introduction to Oral Cancer

Oral cancer accounts for approximately 3-4% of all cancers. It is estimated that approximately 354,000 new cases are diagnosed each year, resulting in approximately 177,000 deaths. Oral cancer is usually associated with abnormal squamous cells in the inner layer of the oral mucosa.

The correlation between epigenetic modifications and oral cancer. Fig.1 Epigenetic modifications play a crucial role in oral cancer. (Aghiorghiesei, O., et al., 2022)

Targets of Oral Cancer Therapy Development

Some molecular targets in oral cancer have been identified, providing opportunities for new therapy development, particularly targeted therapies and immunotherapies. The following are specific targets, related descriptions, and current development status.

Targets	Description
Epidermal Growth Factor Receptor (EGFR)	Overexpression of EGFR is associated with the progression and poor prognosis of oral cancer. Studies have explored the therapy of EGFR by monoclonal antibodies and tyrosine kinase inhibitors.
Vascular Endothelial Growth Factor (VEGF)	It plays a crucial role in promoting angiogenesis, and therapies targeting VEGF or its receptors have been studied to inhibit tumor growth and metastasis.
PI3K/AKT/mTOR Pathway	This signaling pathway is often dysregulated in oral cancer and is involved in cell survival, proliferation, and apoptosis. Inhibitors targeting this pathway have shown promising prospects in preclinical and clinical studies.
Immune Checkpoint PD-1/PD-L1	Blocking immune checkpoints has become a promising strategy for various cancers, including oral cancer. Drugs targeting the PD-1/PD-L1 pathway have shown efficacy.

Therapy for Oral Cancer

Oral cancer therapy involves multidisciplinary methods, such as surgery, radiation therapy, and chemotherapy. Recently, several emerging therapies have also shown promising prospects, including targeted therapy and immunotherapy.

Emerging Therapy

Targeted therapy - Targeting specific molecular targets, such as EGFR inhibitors, angiogenesis inhibitors, and PI3K/AKT/mTOR inhibitors.
Immunotherapy - Related trials for oral cancer have studied strategies such as immune checkpoint inhibitors, adoptive cell transplantation, and cancer vaccines.

Drug Development Pipeline

The drug development pipeline for oral cancer involves multiple stages. Many drugs targeting different molecular pathways are being evaluated, including novel small molecule inhibitors, monoclonal antibodies, and immunotherapy. The main purpose is to evaluate its safety, efficacy, dosage, and side effects.

Controllable administration methods for oral cancer. Fig.2 Controlled drug delivery system for oral cancer therapy. (Ketabat, F., et al., 2019)

Our Services

Oral cancer is a significant public health concern worldwide due to its high incidence rate and associated morbidity and mortality. Alfa Cytology is working on providing one-stop solutions for oral cancer, including but not limited to the following.

Cancer Diagnostic Development

Cancer Modeling Services

Preclinical Research Services

Oral Cancer Modeling Platform

Animal models play a crucial role in oral cancer research to understand the pathogenesis of the disease, evaluate potential therapies, and explore drug action mechanisms. Research on tumor growth can test potential therapies.

Types of Model	Optional Species
3D Tumor Modeling	Mice
Xenograft Model	Rats
Immuno-Oncology Tumor Models	Non-human Primates

Alfa Cytology is committed to the research and study of laryngeal cancer, from immune checkpoint inhibitor development services, and cell therapy development services, to cancer drug development services, providing one-stop solutions. Our cancer experts have many years of experience in the latest therapy for oral cancer. If you are interested in our service, please contact us for more information.

References

Aghiorghiesei, O., et al.; (2022) The World of Oral Cancer and Its Risk Factors Viewed from the Aspect of MicroRNA Expression Patterns. Genes, 13, 594. https://doi.org/10.3390/genes13040594
Ketabat, F., et al.; (2019) Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives. Pharmaceutics, 11, 302. https://doi.org/10.3390/pharmaceutics11070302

For research use only.