Cell Therapy Development Services

Cellular cancer therapies include stem cell- and non–stem cell-based, unicellular, and multicellular therapies, involving different immunophenotypic profiles, isolation techniques, mechanisms of action, and regulatory levels. Alfa Cytology has a wealth of experience in the field of cellular therapeutics research and aims to provide solutions tailored to the developmental challenges encountered by our clients.

Introduction to Cell Therapy

Cell therapy, also known as cellular therapy or cytotherapy, refers to the transfer of living cellular material into the body to repair, regenerate, or replace damaged or dysfunctional cells, tissues, or organs to promote healing and restore normal physiological function for a specific therapeutic purpose. The focus of research and development of cellular drugs includes immune cells and stem cells, which can be derived from a variety of sources, including own body (autologous), a donor (allogeneic), or a cell line. The emergence of cellular therapies has brought new hope in the therapeutic of human diseases, especially autoimmune diseases and malignant tumors. These may further advance the development of precision therapy and bring about changes in conventional therapy.

Fig.1 Current cell therapy categories. (Hsu, L. J., et al., 2021)

Advantages of Cell Therapy for Cancer

Conventional cancer therapeutics (e.g., chemotherapy and radiation) often have significant side effects and may not be effective in all cases. Cell therapy, an innovative way to fight tumor cells, offers several advantages.

• Targeted Therapy. Cellular therapies can specifically target cancer cells, thereby minimizing collateral damage to healthy tissue.
• Immunomodulation. Cell therapies that utilize immune cells can recognize and destroy cancer cells by modulating the body's own immune system.
• Personalized Therapeutics. Cellular therapies can customize therapeutics based on an individual genetic makeup and specific cancer type, resulting in improved efficacy and fewer adverse effects.
• Powerful Anti-Tumor Activity. Engineered immune cells, such as chimeric antigen receptor (CAR) T cells, exhibit potent anti-tumor activity by recognizing and eliminating cancer cells that express specific surface antigens.

Our Services

Immune Cell Therapy Development. Our services are designed to harness the power of the immune system to target and eradicate cancer cells in order to drive innovation in the field of cancer therapy. We specialize in engineering and optimizing various types of immune cells, including immune cell isolation, culture, activation, engineering, expansion and characterization.

• TIL Therapy Development Services for Cancer
• CAR T-cell Therapy Development Services for Cancer
• TCR Therapy Development Services for Cancer
• NK Cell Therapy Development Services for Cancer
• CIK Cell Therapy Development Services for Cancer
• Dendritic Cell Therapy Development Services for Cancer

Stem Cell Therapy Development. Our services are designed to harness the regenerative power of stem cells to target and destroy cancer cells in the body. From stem cell isolation and culture to engineering, expansion, and characterization, our multidisciplinary team of scientists and researchers is dedicated to pushing the boundaries of stem cell technology to develop breakthrough therapeutics that ensure precision and efficacy.

• Autologous Stem Cell Transplant
• Allogeneic Stem Cell Transplant
• Syngeneic Stem Cell Transplant
• Haploidentical Stem Cell Transplant

We offer a one-stop shop program covering all stages of the cell therapy development workflow, from the initial isolation of immune cells or stem cells to their culture, activation, engineering, expansion, and characterization. We can tailor our approach to the unique characteristics of each cell type and cancer subtype, maximizing therapeutic efficacy and minimizing adverse effects. You can browse the services by clicking on the stage of interest in the service flowchart below.

Fig.2 Overview of our services covering the entire workflow of cell therapy development.

Alfa Cytology is a company dedicated to the development of cancer cell therapies. We primarily serve researchers engaged in the development of next-generation therapies worldwide, providing them with services and solutions related to preclinical research. Contact us today to learn more about how we can work together to bring your therapy vision to life.

! For research use only.