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Cell Therapy Development for Prostate Cancer
Cell therapy is an advanced medical therapy that utilizes living cells to treat disease. Alfa Cytology has extensive experience in cell therapy, and aims to provide one-stop development services for cellular therapy for biotech and biopharmaceutical companies worldwide.
Introduction to Cell Therapy
Cell therapy refers to the transfer of new cells, or cells that have been modified in a laboratory to achieve particular characteristics, into the body to prevent or treat a disease. Cell therapy is an emerging therapy that offers better outcomes for prostate cancer. One of the most promising approaches is CAR-T cell therapy, which has been developed to target prostate-specific membrane antigen (PSMA).
Fig. 1 Transperineal
injection of CAR T cells for focal therapy of prostate cancer. (Wolf, P., et al. 2021)
Classification of Cell Therapy
Nowadays, with the continuous development of different cellular therapies, more and more options are available for the therapy of prostate cancer. In the field of prostate cancer, cell therapies mainly include immune cell therapy, tumor-infiltrating lymphocyte (TIL) therapy, and cancer stem cell (CSC) therapy. And cell therapy can also be divided into stem cell- and non–stem cell-based, unicellular and multicellular therapies, with different immunophenotypic profiles, isolation techniques, mechanisms of action, and regulatory levels.
Cell Therapy Development for Prostate Cancer
| Name | Phase | Company | Country |
| PSCA-CAR T | Phase I | Poseida Therapeutics | China |
| P-PSMA-101 | Phase I | Poseida Therapeutics | China |
| GVAX | Phase III | Bayer | Germany |
Our Services
Alfa Cytology is at the forefront of industry trends and deeply understands and foresees that cellular therapy will be the key to treating prostate cancer in the future. Our company has continuously built and improved our core technology platform with the aim of focusing on developing innovative cell therapy technologies, which ensures the high efficiency and feasibility of developing cell therapies without blessings.
Workflow of Cell Therapy Development
Cell selection and enrichment involves identifying and isolating specific types of cells from tissue or blood. The desired subpopulation of cells can be isolated from peripheral blood mononuclear cells (PBMC) using magnetic bead technology and specific antibodies.
Cell modification mainly involves the modification of selected cells through the use of genetic engineering techniques, including the introduction of new genes or functions through gene editing tools, transfection and transduction.
Cells are cultured and expanded under laboratory, and this typically involves the provision of appropriate nutrients, growth factors, and environmental, as well as the use of specific media and culture systems to promote cell activation and proliferation.
Cell characterization is the detailed analysis and testing of cells to confirm their identity, function and safety. It primarily involves the use of tools such as flow cytometry, cell counters, and imaging systems to assess the phenotype, viability, proliferative capacity, and killing activity of cells.
Our Advantages
We are committed to providing efficient, innovative and reliable development solutions by leveraging our in-depth professional knowledge, adopting cutting-edge technologies, and enforcing strict quality control standards.
Professional Knowledge
Cutting-Edge Technologies
Quality Control
Alfa Cytology aims to provide customized one-stop development services to support your innovations and breakthroughs in the field of prostate cancer therapy in order to accelerate the development and commercialization of new therapies. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
Reference
- Wolf, P., et al. The potential of CAR T cell therapy for prostate cancer. Nature reviews. 2021, 18(9): 556–571.
For research use only.