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Chemically Induced Model Development
Chemically induced models are widely used in the field of prostate cancer and are important for the study of the biological process of tumor growth and the development of anti-tumor therapeutic drus. Alfa Cytology is committed to providing our clients with a one-stop for chemically induced models model development, aiming to deliver reliable, reproducible, and translatable models that accurately accelerate the translational process from lab to therapy.
Introduction to Chemically Induced Model
Chemically induced model is a kind of experimental animal model that causes certain damage to animal tissues, organs or the whole body through the use of chemical substances acting on animals, and appears certain functional, metabolic or pathological changes similar to those in human diseases. This kind of model has the characteristics of being able to reproduce a large number of disease models in a short period of time and strictly controlling various conditions so that the reproduced disease models are suitable for the research purpose, thus it is commonly used in modern medical research, especially preferred for drug screening research.
Fig.1 Prostate cancer induction protocol. (Nascimento-Goncalves, E., et al., 2023)
Prostate cancer (PCa) is a common male genitourinary tumor that poses a serious threat to men's health. To understand the molecular mechanisms of prostate cancer pathogenesis and metastasis, the tumor-host relationship, and to evaluate the efficacy of various therapies, it is very important to establish a chemically induced prostate cancer animal model that is close to the clinical phenotype of prostate cancer.
Features to Chemically Induced Model
It is important to choose a suitable animal model of chemically induced prostate cancer and the following are the advantages and disadvantages of this model.
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Our Services
Chemically induced models are an important experimental tool for disease mechanism research and new drug development by mimicking the characteristics of human prostate cancer.At Alfa Cytology, we have a proven platform and a dedicated team working to develop the most appropriate chemically induced prostate tumour models to meet individual customer needs.
N-methyl-N-nitrosourea (MNU) Model
Delivering MNU-induced prostate cancer model development, we offer researchers a tool for studying cancer origins, drug efficacy, and therapy strategies. MNU induces DNA mutations in rats, potentially leading to multi-organ tumors, with protocols ensuring model success for research needs.
3,2'-Dimethyl-4-aminobiphenyl (DMAB) Model
Offering DMAB-induced prostate cancer modeling, this service provides a tool for pathogenesis exploration, drug screening, and therapeutic strategy development. DMAB forms DNA adducts, inducing mutations that mimic prostate cancer progression in mice for in vivo disease modeling.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Model
With PhIP-induced prostate cancer model development, we provide a tool to study the impact of environmental factors on cancer. Feeding mice PhIP simulates human dietary exposure to carcinogens, inducing prostate cancer for pathogenesis study. The model aids in understanding dietary carcinogen effects, though PhIP's complex mechanisms may require additional validation.
At Alfa Cytology, we are committed to providing you with a comprehensive and efficient prostate cancer tumor model development service to support your research and drug development needs. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
Reference
- Nascimento-Goncalves, E., et al. Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions. Anticancer research. 2023, 43(1): 275-281.
For research use only.