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Genetically Engineered Model Development
Genetically engineered mouse models (GEMMs) have been widely used to study the molecular and cellular mechanisms behind prostate tumor initiation and progression, as well as being important for the evaluation of new therapies. At Alfa Cytology, we are committed to providing advanced genetically engineered model development services
Introduction to Genetically Engineered Models
Genetically Engineered Mouse Models (GEMMs) are mouse models in which the mouse genome is artificially modified by means of genetic engineering techniques to produce a mouse model with a specific phenotype or characteristic. Genetically engineered mouse models (GEMMs) play a crucial role in prostate cancer research. Not only do they mimic known genomic alterations in human prostate cancer, they also provide a powerful tool for studying the function of specific genes in tumorigenesis.
Fig. 1 Summary of the development of genetically-engineered mouse models. (Adamiecki, R., et al. 2022)
Types of Genetically Engineered Models
Genetically Engineered Mouse Models (GEMMs) include a range of mice that have been modified through genetic engineering techniques, such as transgenic mice, knockout mice, knock-in mice, conditional and induced knockout mice, as well as mice that have been created using gene editing tools such as CRISPR/Cas9 models. The following table describes the advantages, disadvantages, and applications of knockout mice.
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Our Services
Alfa Cytology is committed to providing a one-stop solution to meet our clients' needs for genetically engineered mouse models (GEMMs) in prostate cancer research and drug development. Our wide range of services, from model design to experimental execution, are designed with excellence in mind at every step to ensure scientific excellence and personalized solutions.
One-Stop Solutions for Genetically Engineered Models
Large-fragment Gene Editing Model
Large-fragment gene editing model development services offered include the non-expression of genes in all tissues and cells throughout the body by knocking out all exons or several important exons and functional regions of the target gene.
Knock-out/Knock-in Model
Targeted gene editing is the tool of choice for gene editing because of its efficiency and precision. Our services include the precise knockout of specific genes using this technology, as well as the precise insertion of specific mutations or exogenous genes into specific loci in the mouse genome.
Transgenic Model
Utilizing different expression vectors to introduce exogenous genes into the mouse genome, we provide different types of transgenic model development services. Our technical team can design and construct transgenic mouse models expressing specific genes or proteins according to the needs of our clients.
With professional technology platform and extensive experience in the industry, Alfa Cytology is committed to providing customers with high-quality mouse models and drug development services. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
Reference
- Adamiecki, R., et al. In Vivo Models for Prostate Cancer Research. Cancers. 2022, 14(21): 5321.
For research use only.