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Humanized Model Development
Humanized models have a wide range of applications in prostate cancer research, which not only contribute to a better understanding of the disease mechanism, but also provide an important experimental platform for the development of new therapeutic approaches, especially immunotherapy. At Alfa Cytology, we are committed to providing advanced humanized model development services
Introduction to Humanized Model
Humanized models are models that can mimic human physiology or pathology by transplanting or transferring human cells, tissues or genes into immunodeficient mice. These models are valuable in basic prostate cancer research, drug screening and vaccine development. Humanized models can be further subdivided into different types, including immune system reconstruction models and target humanization models.
Types of Humanized Model
| Model Types | Description |
| Immune System Reconstruction Model | Immune system reconstruction models, such as Hu-PBMC and Hu-HSC, are used to create human-like immune responses in immunodeficient mice. Hu-PBMC model involves injecting mature lymphocytes to study T cell activation and test immunosuppressive drugs. Hu-HSC model rebuilds the full human immune system, including T and B cells, by injecting hematopoietic stem cells. |
| Target Humanization Model | Target humanization model involves substituting human homologous genes at specific gene loci in the mouse genome to study the function of specific human genes and disease mechanisms. Such models can mimic human gene expression and regulation, including human-specific regulation of non-coding sequences and gene splice isoforms. Target humanization model has unique advantages in studying human gene functions, disease mechanisms, and drug action mechanisms. |
Our Services
At Alfa Cytology, we offer customized humanized mouse model development services, including immune system reconstitution models and target humanization models, to meet your specific needs in prostate cancer research and drug development. Our humanized models mimic the human immune system and tumor microenvironment, providing you with a research platform that more closely resembles the physiology and pathology of the human body.
Immune System Reconstruction Model
By transplanting human immune cells or hematopoietic stem cells into immunodeficient mice, we have developed an immune system reconstitution model that can accurately mimic the human immune response. With the help of this model, researchers can explore the interactions between immune cells and prostate cancer cells, optimize immunotherapy strategies.
Target Humanization Model
By replacing specific genes associated with prostate cancer in mice with human homologs, we offer customized targeted humanized models to meet your specific research needs. Such models can highly mimic the molecular features of human prostate cancer, providing a precise experimental environment for evaluating the efficacy of targeted therapeutic agents.
With professional technology platform and extensive experience in the industry, Alfa Cytology is committed to providing customers with high-quality mouse models and drug development services. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
For research use only.