Metastatic tumor models are important experimental tools used to study the metastatic process of prostate cancer. Alfa Cytology is committed to providing one-stop metastatic tumor model development services. Our goal is to provide you with reliable, reproducible and translatable models.
Prostate cancer is the second most common cancer and the fifth leading cause of cancer death in men, with a lower mortality rate in the non-metastatic stage. However, unlike limited prostate cancer, metastatic prostate cancer has a poorer prognosis, and advanced tumor metastasis is the leading cause of patient death.
Fig. 1 Vicious cycle of cancer proliferation in the bone microenvironment. (Tae, J. H., et al. 2023)
Bone is one of the most common sites of metastasis in advanced solid cancers, with nearly 60% of prostate cancer patients developing bone metastases. Animal models of bone metastatic prostate cancer are important tools for understanding the characteristics of prostate cancer and finding new targets for future therapeutic agents.
At Alfa Cytology, we have established a proven technology platform designed to provide our global customers with efficient and effective prostate cancer metastasis models for prostate cancer research and antitumor drug development. Our team of experts breaks down experimental and technical barriers and focuses on providing customized bone metastatic animal models of prostate cancer, including but not limited to the following.
Table 1. Translational models of prostate cancer bone metastasis
Cell Line | Inoculation Method | Mouse Strain |
Human Cell Lines | ||
DU145 | Intraosseous | Nude and SCID |
LNCaP | Intraosseous | SCID and SCID/bg |
LNCaP | Orthotopic | SCID |
LNCaP C4-2 | Intraosseous | Nude and SCID/bg |
LNCaP C4-2B | Intraosseous | Nude, SCID, and SCID/bg |
PC3 | Intraosseous | Nude, CD-1 nude, and SCID |
Non-Human Cell Lines | ||
ACE-1 | Intracardiac | Nude |
ACE-1 | Intraosseous | Nude |
Human Bone Implant | ||
LNCaP | Intraosseous | NOD-SCID |
PC3 | Intraosseous | NOD-SCID |
DU145 | Intraosseous | NOD-SCI |
Humanized Bone Sponge | ||
LNCaP | Intraosseous | NOD-SCID |
PC3 | Intraosseous | NOD-SCID |
3D In Vitro | ||
LuCaP | Intraosseous | Ragnull and IL-2Rγnull |
Cell Line Selection
Model Construction
Metastasis Monitoring
Data Reporting
With extensive experience in prostate cancer models, Alfa Cytology is the ideal partner to support your therapeutic oncology research. We offer stock model products, model customization and co-development services to provide you with the best tumor models and look forward to meeting your precise needs. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
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