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Metastatic Tumor Model Development

Metastatic tumor models are important experimental tools used to study the metastatic process of prostate cancer. Alfa Cytology is committed to providing one-stop metastatic tumor model development services. Our goal is to provide you with reliable, reproducible and translatable models.

Introduction to Metastatic Tumor Model

Prostate cancer is the second most common cancer and the fifth leading cause of cancer death in men, with a lower mortality rate in the non-metastatic stage. However, unlike limited prostate cancer, metastatic prostate cancer has a poorer prognosis, and advanced tumor metastasis is the leading cause of patient death.

Fig. 1 Vicious cycle of cancer proliferation in the bone microenvironment. (Tae, J. H., et al. 2023)Fig. 1 Vicious cycle of cancer proliferation in the bone microenvironment. (Tae, J. H., et al. 2023)

Bone is one of the most common sites of metastasis in advanced solid cancers, with nearly 60% of prostate cancer patients developing bone metastases. Animal models of bone metastatic prostate cancer are important tools for understanding the characteristics of prostate cancer and finding new targets for future therapeutic agents.

Our Services

At Alfa Cytology, we have established a proven technology platform designed to provide our global customers with efficient and effective prostate cancer metastasis models for prostate cancer research and antitumor drug development. Our team of experts breaks down experimental and technical barriers and focuses on providing customized bone metastatic animal models of prostate cancer, including but not limited to the following.

Table 1. Translational models of prostate cancer bone metastasis

Cell Line Inoculation Method Mouse Strain
Human Cell Lines
DU145 Intraosseous Nude and SCID
LNCaP Intraosseous SCID and SCID/bg
LNCaP Orthotopic SCID
LNCaP C4-2 Intraosseous Nude and SCID/bg
LNCaP C4-2B Intraosseous Nude, SCID, and SCID/bg
PC3 Intraosseous Nude, CD-1 nude, and SCID
Non-Human Cell Lines
ACE-1 Intracardiac Nude
ACE-1 Intraosseous Nude
Human Bone Implant
LNCaP Intraosseous NOD-SCID
PC3 Intraosseous NOD-SCID
DU145 Intraosseous NOD-SCI
Humanized Bone Sponge
LNCaP Intraosseous NOD-SCID
PC3 Intraosseous NOD-SCID
3D In Vitro
LuCaP Intraosseous Ragnull and IL-2Rγnull

Workflow of Metastatic Tumor Model Development

Cell Line Selection

Model Construction

Metastasis Monitoring

Data Reporting

With extensive experience in prostate cancer models, Alfa Cytology is the ideal partner to support your therapeutic oncology research. We offer stock model products, model customization and co-development services to provide you with the best tumor models and look forward to meeting your precise needs. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.

Reference

  1. Tae, J. H., et al. Animal models of bone metastatic prostate cancer. Investigative and clinical urology. 2023, 64(3): 219-228.
notification For research use only.

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