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Therapeutic Vaccine Development for Prostate Cancer
Therapeutic vaccines stimulate the immune system to target cancer cells, and control the progression of disease. Alfa Cytology is committed to providing a comprehensive one-stop development service for the development of multiple types of therapeutic vaccines against prostate cancer.
Introduction to Therapeutic Vaccine
Therapeutic vaccines are one of the most effective medical interventions to combat prostate cancer. Various technological strategies have been implemented for the development of therapeutic vaccines, including molecular-based vaccines (peptide/protein, DNA and mRNA vaccines), vector-based vaccines (bacterial vector vaccines, viral vector vaccines and yeast-based vaccines) and cell-based vaccines (dendritic cell vaccines and genetically modified cell vaccines) as well as combinatorial approaches.
Fig. 1 Antitumour vaccine approaches in prostate
cancer. (Rastogi, I., et al. 2023)
Classification of Therapeutic Vaccine
Although the aims of all vaccinations are the same-to trigger an antigen-specific immune response-not all vaccines work in the same way. There are three broad categories of vaccines currently in use and numerous subcategories, each with different antigenic triggers and delivery systems (vectors).
- Peptide/protein vaccines
These vaccines are made from special proteins in cancer cells, or from small pieces of protein (peptides).
- DNA vaccines
DNA vaccines are bacterial plasmids that are constructed to deliver genes encoding tumor antigens.
- mRNA vaccines
mRNA vaccines are to use messenger RNA (mRNA) to direct the body's cells to produce pathogen-specific proteins.
- Bacterial vector vaccines
The use of live bacteria as a vector to deliver heterologous antigens is an effective and original alternative to the development of new vaccines.
- Viral vector vaccines
Viral vector vaccines are vaccines that use modified viruses to deliver specific antigenic genes from a pathogen to host cells.
- Yeast-based vaccines
Yeast-based vaccines are vaccines that utilize yeast cells as vectors to express specific antigenic proteins of pathogens.
- Dendritic cell vaccines
Dendritic cell vaccine is a vaccine that utilizes Dendritic Cells (DCs) as antigen-presenting cells. Dendritic cells are key players in the immune system, responsible for capturing, processing and presenting antigens to T cells to activate specific immune responses.
- Genetically modified cell vaccines
These vaccines are created by introducing specific antigenic genes into cells, enabling them to express the antigen of a pathogen, thereby triggering the immune system to produce an immune response.
Therapeutic Vaccine Development for Prostate Cancer
| Name | Phase | Company | Country |
| DCvax | Phase III | Northwest Biotherapeutics | USA |
| Sipuleucel-T | Market Approval | Dendreon | USA |
Our Services
There are also therapeutic vaccines that activate the immune system to help treat prostate cancer, including DNA vaccines, mRNA vaccines, spherical nucleic acid vaccines, adenovirus vaccines, and dendritic cell tumor vaccines. Alfa Cytology has been deeply involved in the above therapeutic vaccine development field for many years, and we have a professional team to provide you with 24-hour end-to-end development services to ensure that the entire therapeutic vaccine development process is fast-tracked.
Workflow of Therapeutic Vaccine Development
Selection of Target Antigens
The process of selection of target antigens involves identifying and selecting pathogens or tumor-associated proteins or peptides capable of eliciting a specific immune response to prevent or treat prostate cancer.
Vaccine Design
In vaccine design, a vaccine formulation is developed based on the selected antigen. This mainly includes the construction of antigens, selection of vectors, addition of adjuvants and development of delivery systems to enhance immunogenicity and protective efficacy.
In vitro and Animal Model Testing
In vitro and animal model testing process consists primarily of evaluating the safety, immunogenicity, and efficacy of a vaccine in cell culture and in animal models to determine whether the immune response it induces provides the desired protective effect.
Our Advantages
We are committed to providing efficient, innovative and reliable development solutions by leveraging our in-depth professional knowledge, adopting cutting-edge technologies, and enforcing strict quality control standards.
Professional Knowledge
Cutting-Edge Technologies
Quality Control
In the arena of prostate cancer therapy, therapeutic vaccines have become an increasingly important area of research. Our mission is to advance prostate cancer therapy development by providing a one-stop service for therapeutic vaccine development. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
Reference
- Rastogi, I., et al. Vaccines as therapys for prostate cancer. Nature reviews. Urology. 2023, 20(9): 544–559.
For research use only.