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Tumor-on-a-chip Development
Prostate cancer tumor-on-a-chip is an innovative in vitro tumor model that provides a new platform for drug screening and personalized treatment of prostate cancer. Alfa Cytology provides one-stop Prostate cancer tumor-on-a-chip development service by leveraging its professional technology platform.
Introduction to Tumor-on-a-chip
Tumor-on-a-chip technology is a microfluidic chip platform that provides a precise in vitro model for drug development and treatment of prostate cancer by mimicking the tumor microenvironment. This technology is able to replicate the physiologically relevant physical microenvironment of a tumor, including the interactions between tumor cells and stromal cells, as well as the effects of drugs on tumor cells.
Fig. 1 Prostate-Cancer-on-Chip
conceptual model. (Jiang, L., et al. 2024)
Features of Tumor-on-a-chip
Compared with traditional in vitro models, Tumor-on-a-chip can more realistically simulate the complex physiology of prostate cancer, thus providing new perspectives for advances in prostate cancer treatment. Here is an overview of the key components of 3D bioprinting prostate cancer on a chip:
| key components | Description |
| Microfluidic Channels | Tumor-on-a-chip typically incorporates two or more channels designed to culture tumor cells and stromal cells (such as fibroblasts) separately. These channels are often made from transparent polydimethylsiloxane (PDMS) to allow for microscopic observation |
| Porous Membrane | Channels are separated by a porous membrane that permits the diffusion of cellular secretions, such as signaling molecules, simulating cell-to-cell communication within the tumor microenvironment. Membrane can have varying pore sizes, such as 0.8 microns or 8 microns, to study the impact of different pore sizes on cellular behavior. |
| Cells Types | The microarray contains mainly various prostate cancer cell lines and stromal cells. The stromal cells are usually prostate fibroblasts, such as BHPrS1, which can transform into cancer-associated fibroblasts (CAFs) when co-cultured with tumor cells. |
| Culture Medium Flow | A steady flow of culture medium is maintained through the channels, simulating in vivo blood circulation, providing nutrients to the cells and removing waste. |
Our Services
Development of prostate cancer tumor-on-a-chip is crucial for drug development and therapy of prostate cancer. At Alfa Cytology, our team provides one-stop development services from model design to drug screening with specialized technology platform. Through customized services, we help you make breakthroughs in the field of prostate cancer research and therapy development.
Model Design
The service includes the customization of tumor-on-a-chip models that accurately simulate specific subtypes of prostate cancer, catering to the precise research objectives of our clients. These models are designed to replicate the biological characteristics of tumors, providing a reliable experimental platform for study.
Cell Culture
Included in the service is the co-cultivation of prostate cancer and stromal fibroblast cells on the chip, which duplicates the tumor microenvironment. This technique allows for an in-depth analysis of the interactions between tumor cells and their surrounding cells, offering vital insights into tumor growth and invasion.
Drug Screening
Utilizing the customized tumor-on-a-chip models, drug screening experiments are conducted to assess the efficacy and impact of various drugs on tumor cells. This process is carried out within a controlled microenvironment, ensuring the accuracy and reliability of the results.
Data Analysis
Offer detailed data analysis services, translating complex experimental results into actionable insights on drug mechanisms and therapeutic outcomes.
At Alfa Cytology, our customized microarrays for application modeling provide researchers with powerful tools to study all aspects of prostate cancer cancer biology, drug discovery and toxicity testing. We guarantee that your research endeavors are equipped with superior, dependable prostate cancer tumor-on-a-chip. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
Reference
- Jiang, L., et al. Microfluidic-based human prostate-cancer-on-chip. Frontiers in bioengineering and biotechnology. 2024.
For research use only.