Subcutaneous Tumor Model Development Services
The subcutaneous (SC) tumor model is a commonly used animal experimental model to study tumor growth, metastasis, and therapeutic effects. Alfa Cytology is committed to precise model customization and stringent quality control, aiming to more accurately replicate human tumor biology, thereby advancing the preclinical studies of cancer therapies.
Overview of Subcutaneous Xenograft Tumor Models
Subcutaneous tumor models are tumors transplanted in immunodeficient animals and used to study the sensitivity of human tumors to drugs. Subcutaneous tumor transplantation animal models are widely used in cancer research and anti-cancer drug development due to their simplicity and high tumorigenicity and are the preferred models for initial screening of anti-cancer drugs. It is also an important tool for the meticulous study of tumors and microenvironments.
Fig.1 Induction of different subcutaneous tumor models in mice. (Kranjc Brezar, S., 2024)
Advantages of Subcutaneous Xenograft Tumor Models
Subcutaneous tumor models are an indispensable tool in cancer research, providing important support for the development of new therapies and the understanding of tumor biology because of the following advantages.
Rapid Growth
Due to the direct implantation of the tumor cells into the host, the subcutaneous tumor model grows faster and is able to provide experimental data in a short period of time.
Easy to Operate
Subcutaneous tumor models are relatively simple to set up and maintain, making it easy for researchers to carry out regular monitoring and interventions.
Good Reproducibility
Subcutaneous tumor models can provide consistent results in different experiments, which is suitable for validating the effectiveness and safety of drugs.
Our Services
At Alfa Cytology, we have established an established tumor microenvironment center technology platform with a group of experienced tumor model customization experts and proven technologies designed to provide our global customers with efficient and proven subcutaneous transplant tumor models for tumor and microenvironment research and antitumor drug discovery.
Various Tumor Sources
Subcutaneous tumor models are an efficient and cost-effective option for determining tumor response to new drugs. Tumor cells are implanted into the flanks of mice and tumor growth is monitored by calipers to evaluate anti-cancer therapies in vivo.
- Thoracic Cavity and Ascites
- Established Tumor Cell Lines
Multiple Tumor Types
Our subcutaneous tumor model development services cover a wide range of tumor cell line types to meet different research needs and help researchers explore tumor biology and its therapeutic strategies in depth, which include but not limited to the following.
Breast Cancer
- 4T1 (mouse)
- MDA-MB-231 (human)
- MDA-MB-361 (human)
- BT-474 (human)
- BT-20 (human)
- T-47D (human)
- MCF7 (human)
Bowel Cancer
- CT26WT (mouse)
- LS174T (human)
- DLD-1 (human)
- HCT116 (human)
- HT-29 (human)
- SW620 (human)
Lung Cancer
- LLC1 (mouse)
- A549 (human)
- PC-9/PC-14 (human)
- Calu-6 (human)
Prostate Cancer
- TRAMP-CA (mouse)
- PC-3 (human)
- DU145 (human)
- LNCaP (human)
Melanoma
- A375 (human)
- SK-MEL-1 (human)
- A431 (human)
Workflow of Subcutaneous Tumor Model Development
Consultation and Project Planning
Understand your specific needs and outline the project scope.
Model Selection and Construction
Cell culture, implantation, and selection of appropriate animal models.
Tumor Growth Monitoring
Monitoring the progress through regular measurements of tumor size and growth rate.
Data Analysis and Reporting
Generate detailed reports containing information on tumor growth and drug response.
Support and Consultation
Help clients understand the data and discuss the subsequent experimental design.
Subcutaneous tumor model development services provide an important tool for cancer research and drug development. By utilizing a wide range of tumor sources, our service enables researchers to create models that are closely and reliably related to human disease. These models facilitate comprehensive studies of tumor growth, metastasis, and treatment response, enabling the evaluation of novel compounds and therapeutic strategies. With a focus on model accuracy and reproducibility, we are committed to supporting goodness in oncology research and personalized medicine. Please contact us for more information.
Reference
- Kranjc Brezar, S. (2024). Transplantable Subcutaneous Tumor Models. In Mouse Models of Cancer: Methods and Protocols (pp. 67-76). New York, NY: Springer US.
For research use only.
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