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Brain Tumor

Brain tumors are caused by the growth of abnormal cells in the brain. At Alfa Cytology, we are committed to helping our clients unravel the complexity of these diseases by providing integrated preclinical research solutions.

Introduction to Brain Tumors

Brain tumors are a large group of heterogeneous tumors that affect the central nervous system and include some of the deadliest cancers. Primary malignant brain tumors remain one of the deadliest cancers, despite a better understanding of their tumorigenic processes and a multimodal approach to treatment in recent years. Brain tumors are also the most common solid tumor in children and are the leading cause of cancer-related morbidity and mortality in this population.

Introduction to Brain Tumors.Fig.1 Primary brain tumors and metastatic brain tumors.

Therapy Development for Brain Tumors

The brain tumor diagnosis and treatment market were worth around USD 1,395.7 million in 2021 and is estimated to grow to about USD 2,036.5 million by 2028, with a compound annual growth rate (CAGR) of approximately 6.5 percent over the forecast period.

Promising brain tumor pipeline therapies in various stages of development include:

Sponsors NCT Therapeutics Phase
M.D. Anderson Cancer Center NCT01740570 Cabazitaxel
123
Myrexis Inc. NCT00393965 MPC-6827
123
Rockefeller University NCT00893945 DC/AAT
123
ABM Therapeutics Shanghai Company Limited NCT05892653 ABM-1310
123

The blood-brain barrier (BBB) is a major factor contributing to the inefficiency of various therapies for brain tumors. Through innovative approaches such as nanotechnology-based carriers, receptor-mediated delivery systems and focused ultrasound technology, researchers have made significant advances in improving drug delivery to brain tumors and increasing treatment success.

Therapy Development for Brain Tumors.Fig.2 Brain cancer treated with novel nanoparticle (NP) therapy. (Mitusova, K., et al., 2022)

Our Services

At Alfa Cytology, we are dedicated to providing comprehensive and innovative solutions for all your brain tumor-related needs. Our team of highly skilled professionals, backed by cutting-edge research and state-of-the-art facilities, offers a wide range of services to address the multifaceted aspects of brain tumor management.

Our Brain Tumors Modeling Services

We understand the critical role animal models play in advancing brain cancer research. We offer state-of-the-art animal model development services tailored specifically for brain cancer studies, including pharmacokinetics studies and drug safety evaluation.

Meningiomas Gliomas
  • Syngeneic models
  • GEMMS
  • Tumor like Drosophila models
  • Brain organoids
  • Xenografts: CLX, PDX and PDOX
Ependymomas Medulloblastomas
  • GEMMS
  • Xenografts: PDOX
  • Tumor like Zebrafish models
  • GEMMS
  • Brain Organoids: cerebellar organoids
  • Xenografts: CLX and PDOX

At Alfa Cytology, we are committed to providing comprehensive and cutting-edge solutions for the management of brain tumors. For more information about our brain tumors research and development initiatives, or to inquire about our comprehensive services, please don't hesitate to contact us.

Reference

  1. Mitusova, K., et al.; (2022). Overcoming the blood–brain barrier for the therapy of malignant brain tumor: Current status and prospects of drug delivery approaches. Journal of nanobiotechnology, 20(1), 412.

! For research use only.