Tumor-on-a-Chip Model Development Services
Tumor-on-a-Chip technology represents a groundbreaking approach to cancer research by integrating microfluidics, biomaterials, and cell culture techniques to create dynamic and physiologically relevant models of tumors. At Alfa Cytology, we leverage our expertise in microfabrication and tissue engineering to develop Tumor-on-a-Chip platforms that faithfully recapitulate key aspects of the tumor microenvironment, including nutrient gradients, fluid flow, and cellular interactions.
Introduction into Tumor-on-a-Chip Model
The tumor microenvironment is a complex and dynamic ecosystem characterized by spatial heterogeneity, cellular interactions, and physiological gradients. Traditional in vitro models often fail to capture these complexities, leading to limitations in translational relevance and therapeutic efficacy. Tumor-on-a-chip platforms address these limitations by providing a more physiologically relevant platform for studying tumor biology and evaluating therapeutic interventions.
Fig.1 Schematic of the tumor-on-a-chip platform. (Liu, X., et al., 2021)
In vitro tumor-on-a-chip models replicate key aspects of the tumor microenvironment using advanced microfabrication techniques. They allow for the study of tumor progression, angiogenesis, metastasis, and drug responses. Highlighted models include lung, liver, brain, colorectal, breast, and pancreatic tumor chips, offering insights into high-morbidity cancers for improved therapeutic development.
| Tumor-on-a-chip models |
Cell types |
Applications |
| Lung tumor chip |
Human NSCLC cell line |
Explain the high level of resistance to therapy in lung cancer patients and provide an experimental model to study cancer persister cells and mechanisms of tumor dormancy in vitro. |
| Human alveolar epithelial cells and human pulmonary microvascular endothelial cells |
Reconstitute the critical functional alveolar–capillary interface of the human lung to response to bacteria and inflammatory cytokines introduced into the alveolar space. |
| Brain tumor chip |
Brain tumor stem-like cells |
Examine the function of primary patient-derived BTSCs. |
| Glioblastoma cells (U87) |
Develop a 3D brain cancer chip for drug screening. |
| C6 glioma cells |
Study the cellular response to different concentrations of colchicines. |
| Liver tumor chip |
- HepG2/C3A
- MEG-01
- MES-SA
- MES-SA/DX-5
|
Provide a combined strategy for selectively inhibiting MES-SA/DX-5 cell proliferation; may prove to be advantageous in vivo by specifically targeting MDR cancer with acceptable side-effects. |
| iPSC2a |
Refine microtissues, establish modular multi-tissue platforms, and study interactive responses of cardiac, vascular and hepatic microtissues to pharmacological agents and to physiological and pathological stimuli. |
| Functional endothelial cells |
| Cardiomyocytes hepatocytes |
| Colorectal-tumor chip |
CRC cell line HCT-116 |
Evaluate precision nanomedicine delivery. |
| Breast tumor chip |
MDA-MB-453, MDA-MB-231, and HCC1937 |
Develop a microfluidic device for a 3D breast cancer screening platform. |
|
|
| Pancreatic tumor chip |
MIA PaCa-2 |
Replicate cellular morphologies and reflect the death of endothelial cells during the metastasis process. |
| BxPC3 |
| HT-29 |
| HepG2s |
Provide a suitable platform for pancreatic cancer cell growth for studying the metastasis of pancreatic cancer. |
| MSCs |
| HUVECs |
Our Services
Our tumor-on-a-chip model development services offer researchers a versatile and customizable platform for studying various aspects of tumor biology, including tumor angiogenesis, drug transport, immune cell dynamics, and therapeutic resistance. By integrating microfluidic channels, biomimetic scaffolds, and live cell imaging, we create Tumor-on-a-chip platforms that accurately mimic the in vivo tumor microenvironment and enable real-time analysis of cellular behavior and response to treatment. Our tumor-on-a-chip platforms are included but not limited as follows:
Alfa Cytology is a leader in Tumor-on-a-Chip model development, dedicated to advancing cancer research and therapeutic development through innovative and cutting-edge technologies. With a multidisciplinary team of experts, state-of-the-art facilities, and a commitment to excellence, we empower researchers and pharmaceutical companies to accelerate the pace of discovery and translation in the fight against cancer. Contact us today to learn more about our Tumor-on-a-Chip Model Development Services and how we can support your research endeavors.
Reference
- Liu, X., et al.; (2021). Tumor-on-a-chip: from bioinspired design to biomedical application. Microsystems & Nanoengineering, 7(1), 50.
For research use only.
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