Exosome-Based Analysis Services for Bladder Cancer

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Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nanometers that play an important role in cellular communication and metastasis of bladder cancer. Alfa Cytology offers comprehensive exosome-based analysis services for you.

The Function of Exosome in Bladder Cancer

Bladder cancer is characterized by its heterogeneity and aggressive nature, making it difficult to diagnose and treat effectively. Some explorations have demonstrated that exosomes have demonstrated immense potential as liquid biopsy markers for the diagnosis and prognosis of bladder cancer. They can also serve as therapeutic targets and drug delivery vehicles, enabling targeted and efficient therapeutic strategies. Therefore, it is crucial for the analysis and characterization of exosomes from bladder cancer cells, immune cells, and stromal cells.

Fig.1 Summary of the biogenesis, function, expression profiles, and biological mechanisms of exosomes and their contents in bladder cancer diagnosis, prognosis, and drug delivery. (Yang, Y., et al. 2023)

Our Services

At Alfa Cytology, we offer a diverse range of exosome-based analysis services that are tailored specifically for bladder cancer research. Our services encompass various aspects of exosome analysis, including isolation and purification, identification, marker assay, labeling and tracking, and multi-omics analysis.

Exosome Isolation and Purification

Exosome Isolation and Purification
We employ techniques such as ultracentrifugation, density gradient centrifugation, and size exclusion chromatography to isolate exosomes from different biological fluids, including blood, urine, and tissue samples. And, we can pass pure exosomes, free of contaminants and suitable for downstream analysis.

Exosome Identification
Precise identification of exosomes is essential to distinguish them from other extracellular vesicles and cellular debris. To address this, we employ a combination of techniques such as nanoparticle tracking analysis (NTA), electron microscopy, and flow cytometry to confirm the presence of exosomes and validate their characteristics in the isolated samples.

Exosome Identification

Exosome Marker Assay

Exosome Marker Assay
Exosomes carry specific markers that reflect their cellular origin and cargo content. We utilize advanced immunoassays, including ELISA and Western blotting, to accurately detect and quantify exosome-specific markers. These markers include tetraspanins (CD63, CD9), heat shock proteins (HSP70, HSP90), and tumor-specific antigens.

Exosome Labeling and Tracking
To further understand the behavior and interactions of exosomes in the context of bladder cancer, we offer exosome labeling and tracking services. Through fluorescence-based labeling techniques, we can visualize and monitor the uptake, distribution, and trafficking of exosomes in both in vitro and in vivo settings.

Exosome Labeling and Tracking

Our Services Will Help You Achieve the Following Goals:

Identification and characterization of exosomal biomarkers specific to bladder cancer.
Assessing the prognosis of bladder cancer by analyzing exosomal cargo.
Identifying potential therapeutic targets specific to bladder cancer.
Assisting in optimizing exosome-based drug delivery strategies in bladder cancer.

Contact Us

Alfa Cytology is your trusted partner in advancing bladder cancer research through our single-cell omics profiling services. Our expertise, cutting-edge technologies, and comprehensive service portfolio enable researchers to unravel the complexity of bladder tumors, study cellular heterogeneity, and identify novel therapeutic targets. For more information about our exosome-based analysis services for bladder cancer or to discuss your specific research needs, please contact us today.

Reference

Yang Y., Miao L., and et al. Exosome, the glass slipper for Cinderella of cancer—bladder cancer? J Nanobiotechnol. 2023, 21, 368.

For research use only. Not intended for any clinical use.

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* Please note that we are not a pharmacy or clinic, so we do not offer diagnostic and treatment services for patients.

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