Cell Therapy Development for Breast Cancer
Introduction of Cellular Immunotherapies
Breast cancer (BC) is one of the malignant tumors that seriously threaten women's life and health. Traditional treatment methods have the disadvantages of "easy transfer and side effects". Cellular immunotherapy is an emerging BC treatment method. By activating or restoring the tumor-killing function of the human immune system, it can effectively avoid cancer recurrence and metastasis, and further improve the survival rate of BC patients. At present, the main therapies include cytokine-induced killer cell therapy, dendritic cell therapy, CAR-T therapy, CAR-NK therapy, ACTL tumor cell-targeted therapy, CLS therapy, DC-T cell therapy, etc.
Fig. 1. From MSCs to CAR-MSCs in cellular immunotherapy. (Yan L, et al., 2023)
Breast Cancer Cellular Immunotherapies Development Services
Alfa Cytology can provide you with BC cellular immunotherapy development services. Cellular immunotherapy can help the immune system identify and attack specific cancer cells, strengthen immune cells, destroy cancer, and provide the body with additional substances to enhance the body's immune response. Our services include:
| Services | Description |
|---|---|
| Breast cancer CAR-T cell therapy | Chimeric antigen receptor T cell immunotherapy (CAR-T) is a new type of precisely targeted therapy for tumors that combines gene therapy and cell therapy technologies. T cells are collected from the human body, genetically modified to express a type of CAR-T cell that can recognize and attack cancer cells, and then injected into the body to exert anti-tumor activity. |
| Breast cancer CAR-NK cell therapy | CAR-NK is a surface CAR-modified by genetic engineering, which links effective antibodies that recognize the surface of target cells with the signaling molecules required to activate immune cells. CAR-NK cells are strong candidates for targeted therapy of BC because of their unique cell recognition mechanism, high cytotoxicity, and robust safety profile. |
| Breast cancer TIL cell therapy development | TIL is an infiltrating immune cell isolated from tumor tissue that responds to tumor cells. These immune cells have the ability to recognize and attack tumor cells and can penetrate deep into the interior of tumor tissue. TIL therapy is a method that uses the tumor's own immune cells to kill the tumor. TIL therapy has the advantages of multiple targets, strong tumor tendency and infiltration ability, and small side effects. |
| Breast cancer therapy development targeting TAMs | Tumor-associated macrophages possess antitumor, tumor-promoting heterogeneity, and differentiation plasticity. In the early stages of tumorigenesis, TAMs exhibit an inflammatory phenotype. As tumors progress, TAMs gradually exhibit an anti-inflammatory phenotype. Current studies have shown that TAMs can effectively inhibit tumor growth and proliferation, so TAMs are potential anti-tumor targets. |
Advantages of Cellular Immunotherapy
- High security
- Targeted
- Persistence
- Comprehensiveness
- Wide range of indications
Alfa Cytology' team is composed of highly educated and highly qualified professionals with good professional backgrounds and BC research experience. If you are interested in learning more about our BC cell immunotherapy development services, please feel free to contact us. Our professional and patient staff will contact you as soon as possible.
Reference
- Yan L, et al. The role of MSCs and CAR-MSCs in cellular immunotherapy. Cell Commun Signal. 2023 Aug 1;21(1):187.