Leukemia

Leukemia, a devastating hematological malignancy, has long been a formidable challenge in the realm of oncology. At Alfa Cytology, we have dedicated to unraveling the complexities of this disease, driven by a relentless pursuit of innovative solutions.

Introduction to Leukemia

Leukemia is a type of cancer that originates in the haematopoietic tissues (mainly the bone marrow and lymphatic system).

Fig.1 Cytology of leukemia.

Leukemia is broadly classified into four main types:

Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)

Chronic Lymphocytic Leukemia (CLL)
Chronic Myeloid Leukemia (CML)

Pathogenesis of Leukemia

One of the hallmarks of leukemia is the accumulation of genetic mutations, which can disrupt the normal regulation of cell growth, proliferation, and survival.

Fig.2 NF-κB pathway mutations in chronic lymphocytic leukaemia. (Fabbri, G., & Dalla-Favera, R., 2016)

Therapy Development for Leukemia

Promising leukemia pipeline therapies in various stages of development include:

Drugs	Company	Phase	MoA	RoA
Omidubicel	Gamida Cell	Registered	Cell replacements	Intravenous
Uproleselan	GlycoMimetics	Phase III	E-selectin inhibitors	Intravenous
Pevonedistat	Takeda Oncology	Phase III	NEDD 8 activating enzyme inhibitors	Intravenous
SKLB1028	CSPC Ouyi Pharmaceutical	Phase III	Bcr-abl tyrosine kinase inhibitors; Epidermal growth factor receptor antagonists; Fms-like tyrosine kinase 3 inhibitors; Lyn protein-tyrosine kinase inhibitors	Oral
BPX-501	Bellicum Pharmaceuticals	Phase II	Immunologic cytotoxicity; T lymphocyte replacements	Intravenous
ALT 803	ImmunityBio	Phase II	Interleukin-15 receptor agonists	Intravenous

Our Services

At Alfa Cytology, with a team of highly skilled and experienced biological experts who have worked in the industry for many years, our company understands the unique challenges associated with leukemia therapy and is committed to providing cutting-edge solutions. We have developed a profound understanding of the molecular mechanisms of leukemia and have conducted extensive research in this field.

Therapeutics Development

Diagnostic Development

Preclinical Research

Small Molecule Drug
Cell Therapy
Gene Therapy

Cancer Biomarker Discovery
Imaging Services
Multi-omics Services

Molecular Biology Services
Tumorigenesis Analysis
Cancer Metabolism Analysis

Our Leukemia Animal Model Development Services

Preclinical animal models play a crucial role in the development of novel leukemia therapies. We offer a specialized service for the development and characterization of advanced leukemia animal models.

Animal Models

Spontaneous ALL Animal Models
Chemical-Induced ALL Animal Models
Xenotransplantation ALL Animal Models
Transgenic ALL Animal Models

Cell Line Models

K-562
KU-812
Bv-173
EM-2/EM-3
NALM-1
JK-1

In Vitro 3D AML Models

Synthetic Scaffold-Based 3D Models
Biologic Scaffold-Based 3D Models
Dynamic 3D In Vitro Models

Optional Species

Mouse
Rats
Zebrafish
Non-human Primates
Others

For more information about our leukemia research and development initiatives, or to inquire about our comprehensive services, please don't hesitate to contact us at Alfa Cytology. Our dedicated team of experts is committed to collaborating with healthcare providers and research institutions to drive progress in the fight against leukemia.

Reference

Fabbri, G., & Dalla-Favera, R. (2016). The molecular pathogenesis of chronic lymphocytic leukaemia. Nature Reviews Cancer, 16(3), 145-162.

For research use only.