Efficacy Evaluation Services

Conventional methods for preclinical discovery, particularly target validation approaches, face challenges in predicting drug efficacy. Alfa Cytology offers comprehensive services to support your research on the therapeutic efficacy of drugs for leukemia. Our leukemia models are provided to assess drug efficacy and predict safety.

Introduction to Efficacy Evaluation

The study of drug efficacy holds significant importance in leukemia treatment and therapy research. Evaluating drug efficacy involves the process of determining the effectiveness of drugs in treating leukemia. Predicting treatment response remains highly challenging in acute myeloid leukemia. Integrating genomic data, including mutations and gene expression, along with large-scale drug screening, enables the prediction of drug efficacy in leukemia.

Fig. 1. Prediction model for drug response of acute myeloid leukemia. (Trac, Q.T. et al., 2023)

Our Services

As a preclinical CRO supplier, we provide top-notch efficacy evaluation services for leukemia research and drug development. With a wide range of leukemia cell lines and animal models at our disposal, we can support your research and assess the effectiveness of potential drugs. Here are the key highlights of our services.

In Vitro Pharmacology Services

Utilizing advanced leukemia cell lines, we conduct responsiveness assessments of new compounds, targeted therapeutics, or combination treatment regimens. Our in vitro pharmacology services offer a range of experimental techniques to investigate the effects of drugs and compounds on biological systems outside of a living organism.

Cell-Survival and Cell Growth-Inhibition Assays
Biochemical Assays
Ion Channels Assays
Phenotypic Screening Services
Co-Cultivation Assays

Ex Vivo Analysis of the Tumor Microenvironment
Protein-Protein Interaction Detection
Cellular and Selectivity Screens
Signaling Pathway Assays

In Vivo Pharmacology Services

We possess a diverse range of leukemia animal models for in vivo evaluation of drug efficacy. Monitoring parameters such as tumor growth, hematological indicators, splenic and bone marrow pathology changes, we assess the effectiveness of candidate drugs throughout the treatment process. We offer different animal models of leukemia for in vivo pharmacology experiments.

Spontaneous Models

Genetically Engineered Models

Leukemia Xenograft Model

Syngeneic Leukemia Models

Advantages of Our Services

Our team comprises highly skilled experts with extensive experience in the field of leukemia research and drug development.
This comprehensive approach we provide ensures a thorough assessment of drug efficacy from multiple angles.
We utilize state-of-the-art technology and cutting-edge techniques in our efficacy evaluation services.
We understand that each research project is unique, and we tailor our services to meet specific client requirements.

Contact Us

Alfa Cytology are dedicated to providing comprehensive efficacy evaluation services for leukemia research, assisting clients in advancing their drug development efforts. Whether it's early-stage drug screening or in-depth efficacy assessments, we ensure exceptional technical support and expert knowledge, guaranteeing optimal outcomes for your research endeavors. Contact us for more details on our services.

Reference

Trac, Q.T.; et al. Prediction model for drug response of acute myeloid leukemia patients. NPJ Precision Oncology. 2023, 7(1): 32.

For research use only. Not intended for any clinical use.