Therapeutic Antibody Development for Leukemia
Welcome to Alfa Cytology, we are committed to the exciting field of developing antibodies for leukemia therapy. We will fully participate in the technology and development processes related to this pioneering research field.
Introduction to Therapeutic Antibody
Leukemia is a group of blood cancers characterized by abnormal production of white blood cells, which poses significant challenges to current therapies. However, the latest advances in the development of therapeutic antibodies have opened up new avenues for combating this disease. Therapeutic antibodies have unique advantages, including targeting specificity and reducing side effects, making them increasingly promising methods in leukemia therapy.
Fig. 1. Methods for developing therapeutic antibodies. (Lu, RM.; et al., 2020)
The development of antibodies for leukemia involves a complex multi-step process. The development service process usually starts with target recognition, carefully selecting specific proteins or markers expressed on leukemia cells. After determining the targets, various techniques will be used to generate antibodies that specifically bind to these targets, such as hybridoma technology or through the use of phage display or yeast display libraries. After antibody generation, extensive preclinical testing will be conducted to evaluate its efficacy, specificity, and safety. Alfa Cytology provides a variety of antibody-related development services, including but not limited to the following.
The Workflows of Therapeutic Antibody Development
Target Identification
Identify and validate target molecules associated with leukemia and determine the relevance of the target and the potential for therapeutic interventions.
Design immunogenic and stable antigens using bioinformatics methods and protein expression systems.
Hybridoma technology and phage display methods are commonly used to screen and identify candidate antibodies with the required specificity and affinity.
Antibody Engineering and Optimization
At this stage, high-throughput screening methods are used to evaluate and optimize the binding affinity and specificity of the generated candidate antibodies.
Antibody Characterization and Production
Antibody characterization includes binding affinity, specificity, and effector function. Then use hybridoma technology or recombinant DNA technology to produce antibodies.
Preclinical In Vitro and In Vivo Testing
Cell-based assays were used for in vitro testing, and in vivo testing was conducted in animal models to verify the efficacy and safety of the developed antibodies.
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Alfa Cytology's multidisciplinary expert team, state-of-the-art technology, and commitment to excellence make us an ideal partner for organizations seeking to develop innovative antibody therapies. Please contact us immediately to discuss how our antibody characterization services can contribute to the success of your research.
Reference
- Lu, RM., et al. Development of therapeutic antibodies for the treatment of diseases. J Biomed Sci 27, 1 (2020). https://doi.org/10.1186/s12929-019-0592-z.