Orthotopic Tumor Model Development Services
The orthotopic tumor model is an experimental model in which a tumor is established in its natural location in the animal body, which can more realistically reflect the biological characteristics and microenvironment of the tumor. Alfa Cytology provides orthotopic tumor model development services to support tumor research and new drug development.
Introduction to Orthotopic Tumor Models
In situ transplantation tumor animal models are established by transplanting tumor cells into the organ of origin of that tumor, such as liver cancer cells/tissue transplanted into the liver or gastric cancer cells/tissue transplanted into the stomach. It provides the same in vivo microenvironment as the origin of the tumor cells, maintains the original biological properties of the tumor cells, has high clinical relevance, can accurately predict drug efficacy, and reduces the incidence of false positives. It is also possible to fully consider the role of the tumor microenvironment when studying tumor progression and treatment strategies, as well as to fully consider the interaction between tumor cells and their surrounding interstitial organ microenvironment when evaluating drug efficacy and monitoring tumor growth.
Fig.1 Comparison of the tumor microenvironment in preclinical murine models of orthotopic and ectopic triple-negative breast cancer. (Santana-Krímskaya, S. E., et al. 2022)
Advantages of Orthotopic Tumor Models
Orthotopic tumor models provide powerful support for oncology research because of their unique advantages, helping researchers to better understand tumor biology and its response to treatment.
Natural Tumor Microenvironment
Orthotopic tumor models can be established at the primary site of the tumor and preserve the interaction between the tumor and the surrounding tissues, providing a biological environment closer to that of human tumor growth.
Excellent Biological Relevance
Compared with xenograft models, orthotopic tumor models reflect the natural growth process and metastatic characteristics of tumors better, which helps to evaluate the effect of drugs in practical applications.
Wide Applicability
Orthotopic tumor models are suitable for a wide range of tumor types, including solid tumors and metastatic tumors, and can be used for different experimental designs and research objectives.
Our Services
At Alfa Cytology, we have established a sophisticated tumor microenvironment center technology platform, a team of experienced tumor model customization experts, and proven technology to provide our global customers with efficient and proven in situ transplanted tumor models for tumor and microenvironment research and antitumor drug discovery.
Multiple Model Types
Multiple types of tumors in situ implants are offered for the development of customized tumor models to facilitate drug discovery projects.
Workflow of Orthotopic Tumor Model Development
Consultation and Project Planning
Understand your specific needs and outline the project scope.
Model Selection and Construction
Implantation of a suitable tumor cell line ensures that the it grows in situ.
Tumor Growth Monitoring
Monitoring the progress through regular measurements of tumor size and growth rate.
Data Analysis and Reporting
Generate detailed reports containing information on tumor growth and drug response.
Support and Consultation
Help clients understand the data and discuss the subsequent experimental design.
With extensive experience in various cancer models and expertise in tumor and microenvironment, Alfa Cytology is the ideal partner to support your oncology therapeutic research. We provide customers with stock model products, model customization, and joint R&D services to provide you with the best tumor models and look forward to meeting your precise needs. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to
contact us.
Reference
- Santana-Krímskaya, S. E., et al.; (2022). Orthotopic and heterotopic triple negative breast cancer preclinical murine models: A tumor microenvironment comparative. Research in Veterinary Science, 152, 364-371.
For research use only.
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