Stomach Cancer

Stomach cancer, also known as gastric cancer, is a formidable disease that continues to pose significant challenges in the realm of oncology. At Alfa Cytology, our team of seasoned biological experts has dedicated themselves to unraveling the intricate mechanisms underlying stomach cancer development and progression.

Introduction to Stomach Cancer

Stomach cancer is the 5th most common and the 5rd deadliest cancer worldwide, according to the latest report of the International Agency for research on Cancer. As a leading cause of cancer-related deaths worldwide, stomach cancer's burden extends far beyond its incidence, with its complex pathogenesis, cellular heterogeneity, and elusive therapeutic targets necessitating a multi-faceted approach to combat this deadly malignancy.

Current Therapies for Stomach Cancer

Despite the role of conventional treatments, the limited efficacy and toxicity have driven the search for more personalized therapies. The promising landscape of stomach cancer research has been fueled by a deeper understanding of the disease's pathogenesis and the emergence of cutting-edge technologies. Researchers and pharmaceutical companies are actively exploring novel therapeutic strategies, including targeted therapies, immunotherapies, and combination approaches, to overcome the limitations of traditional treatment modalities.

Below is a summary of molecules that can be used as potential biomarkers and therapeutic targets for stomach cancer.

Molecule/Strategy	Targets	Known/Tested Use in Stomach Cancer
Anti-CA19-9 antibodies	CA19-9	CA19-9-positive stomach cancer biomarker for diagnosis
Cetuximab	EGFR	Potential targeted therapy against tyrosine kinase receptors
Rilotumumab	HGF	Potential targeted therapy against tyrosine kinase receptors
Dovitinib	VEGFR-1/2/3; PDGFR-β; FGFR1/2/3	Potential targeted therapy against tyrosine kinase receptors
Anti-FGFR2 antibodies	FGFR2	Under clinical trial for FGFR2 overexpressing GC
Nimutuzumab	EGFR	Under clinical trial for EGFR high GC
Everolimus	mTOR pathway	Under clinical trial for MSI type GC with activating mutations of mTOR pathway members
Anti-HDGF antibodies	HDGF	Potential prognostic marker & target of H. pylori-induced GC
AMS 337	c-Met	Positive results in Phase I clinical trial
Exosomes-delivered c-Met siRNA	c-Met	Potential use as therapy in combination with chemotherapy
BST2 siRNA	BST2	Inhibits GC cell proliferation and motility – potential anti-GC therapy
Anti-CEACAM6 antibodies	CEACAM6	Potential endoscopic marker for early GC diagnosis

Our Services

This surge in market size underscores the increasing demand for effective and innovative therapy solutions. At Alfa Cytology, we are committed to advancing the field of stomach cancer research and translating cutting-edge scientific discoveries into tangible clinical benefits. Our comprehensive suite of services encompasses the full spectrum of preclinical research, from target identification and validation to the evaluation of novel therapeutic strategies.

We provide one-stop solutions for stomach cancer, including but not limited to the following.

Modeling Services of Stomach Cancer

Studying the complexities of stomach cancer requires the utilization of robust and clinically relevant experimental models. At Alfa Cytology, we have established a comprehensive array of in vitro and in vivo models that faithfully recapitulate the diverse facets of gastric malignancies, from the genomic and molecular landscapes to the intricate tumor-microenvironment interactions.

Types	Models	Applications
In Vitro Models	Patient-Derived Cell Lines Organoid Cultures	High-Throughput Drug Screening Target Validation Evaluation of Novel Therapeutic Strategies
In Vivo Models	Patient-Derived Xenografts Genetically Engineered Mouse Models	Assessment of Therapeutic Efficacy Pharmacokinetics Safety Assessment

From building customized in vitro and in vivo models to conducting comprehensive preclinical studies, Alfa Cytology strives to help clients accelerate the development of novel therapeutic strategies. Our cancer experts have many years of experience in the development of the latest therapies for stomach cancer. If you are interested in our service, please contact us.

For research use only.