Ovarian Cancer Pathogenesis Analysis

The pathogenesis of ovarian cancer is multifaceted, influenced by genetic factors, hormonal balances, inflammatory processes, and more. Alfa Cytology brings a wealth of research experience to this field, committed to exploring the various pathogenic mechanisms of ovarian cancer. We continuously engage in pioneering research, employing state-of-the-art technologies and methodologies to unveil the underlying causes of ovarian cancer.

Introduction to Ovarian Cancer Pathogenesis

Ovarian cancer pathogenesis involves genetic mutations (e.g., BRCA1 and BRCA2), hormonal fluctuations (e.g., prolonged estrogen exposure), reproductive history (e.g., nulliparity), and chronic inflammation. Genetic mutations cause abnormal cell proliferation, while hormonal levels and reproductive history affect ovarian health. Chronic inflammation and changes in the tumor microenvironment further promote cancer development. Together, these factors interact through complex pathways, driving ovarian cancer evolution.

Signals of Interest in Ovarian Cancer Development Fig 1. Schematic representation of metastasis of ovarian cancer. (HE L, et al., 2019)

Factors Influencing Ovarian Cancer

The pathogenesis of ovarian cancer is influenced by a number of factors, and the following are some of the major risk factors:

Genetic

BRCA1 and BRCA2 Gene Mutations: Mutations in these genes significantly elevate the risk of ovarian cancer, especially among women with a family history of ovarian or breast cancer.

Hormonal

Estrogen Exposure: Prolonged exposure to estrogen, such as in cases of childlessness, early menstruation, or late menopause, may increase the risk of developing ovarian cancer.

Reproductive History

Reproductive Status: Women with little to no reproductive history are at a higher risk of ovarian cancer compared to women who have experienced childbirth.

Inflammation and Chronic Irritation

Chronic Ovarian Inflammation: Long-term inflammation or irritation of the ovaries can lead to cell mutations, thereby increasing the risk of cancer.

Our Services

Alfa Cytology is dedicated to the in-depth study of the complex mechanisms underlying ovarian cancer. Utilizing advanced technologies, we aim to explore the root causes of its pathogenesis. Our research focuses not only on genetic and hormonal factors but also on changes in the tumor microenvironment.

Ovarian Cancer Progression Analysis

Conducting a comprehensive assessment of ovarian cancer progression, analyzing the disease’s spread and development using advanced imaging techniques, biomarker testing, and detailed tissue analysis.

Gene Expression Profiling
Chromatin Immunoprecipitation Sequencing (ChIP-Seq)
Invasion and Migration Assays
Multiplex Immunohistochemistry (IHC)
Mass Spectrometry-Based Proteomics
High-Throughput Genomic and Epigenomic Sequencing
Single-Cell RNA Sequencing
CRISPR/Cas9 Functional Genomics

Ovarian Cancer Metastasis Analysis

Focused on identifying and monitoring the dissemination of cancer cells to other parts of the body, we employ cutting-edge imaging technologies, biopsy techniques, and biomarker analyses.

Tumor Heterogeneity Analysis
Tumor Angiogenesis Analysis
EMT and Tumor Metastasis Analysis
Analysis of Genetic Factors in Tumorigenesis
Analysis of Tumor Cell Heterogeneity and Plasticity
Analysis of Tumor Lymph Angiogenesis and Lymph Node Metastasis
Analysis of Pre-Metastasis in TME

Alfa Cytology, equipped with state-of-the-art laboratory instruments and supported by a highly skilled technical team, is dedicated to advancing our understanding of ovarian cancer pathogenesis. Our team of specialized experts is committed to conducting groundbreaking research aimed at combating this devastating disease. For any inquiries about our services, please feel free to contact us.

Reference

HE L, ZHU W, CHEN Q, et al. Ovarian cancer cell-secreted exosomal miR-205 promotes metastasis by inducing angiogenesis [J]. Theranostics, 2019, 9(26): 8206-20.

! For research use only.