Sex cord-stromal tumors (SCSTs) represent a rare and heterogeneous group of tumors originating from the sex cord and stromal cells of the ovaries and testes. These tumors account for approximately 5-8% of all ovarian and testicular neoplasms. Alfa Cytology, leveraging its dedicated technical team and cutting-edge research capabilities, is committed to deepening the scientific exploration of sex cord-stromal tumors.
Introduction to Sex Cord-Stromal Tumors
Sex cord-stromal tumors (SCSTs) are rare ovarian tumors originating from the sex cords or stromal cells of the ovary, or both. They represent a small fraction of ovarian neoplasms, with benign SCSTs comprising under 4% of benign ovarian tumors and malignant ones less than 8% of malignant ovarian tumors. Despite their rarity, SCSTs are clinically significant for their hormone-secreting potential, causing various endocrinological symptoms.
Fig 1. Common alterations in sex cord-stromal cell tumors. (MAOZ A, et al., 2020)
Pipeline of Therapeutic Development for Sex Cord-Stromal Tumors
Below is a pipeline of some of the drugs in development for sex cord-stromal tumors therapeutics.
|
Company |
Targets |
Name |
Molecule Type |
Phase |
| Pfizer |
PARP Inhibitor |
PF-07104091 |
Small Molecule |
|
| Merck |
PD-1 Receptor |
KEYTRUDA |
Antibody |
|
| GlaxoSmithKline |
Poly (ADP-ribose) Polymerase (PARP) 1/2 Inhibitor |
Niraparib Zejula |
Small Molecule |
|
| Novartis |
PI3K-Alpha Inhibitor |
Piqray® |
Small Molecule |
|
| ImmunoGen |
FRα |
GLORIOSA |
Small Molecule |
|
Our Services
Alfa Cytology, leveraging its exceptional technical team and advanced research facilities, is at the forefront of scientific exploration in the field of sex cord-stromal tumors. By investigating these genetic and molecular alterations, Alfa Cytology aims to drive innovation in therapeutic strategies.
Cell Lines of Sex Cord-Stromal Tumors
- K4/20 and K4/40: These are granulosa cell tumor cell lines derived from human ovarian granulosa cell tumors.
- COV434: Originally derived from a human granulosa cell tumor, this line is frequently used for studies related to granulosa cell tumors and their biology.
- KGN: A steroidogenic human granulosa-like tumor cell line that is commonly used in research focusing on the hormonal activity of these tumors.
- C7 (CRL-1691): This hybridoma cell line is used in immunology research and is derived from the mouse Mus musculus.
Workflow of Sex Cord-Stromal Tumors Drugs Discovery
Target Discovery and Validation
Identify key molecular targets in sex cord-stromal tumors through genomic and proteomic studies, focusing on signaling pathways and genetic mutations driving growth. Investigate interactions between tumor cells and their microenvironment, including stromal and immune cells, to uncover factors promoting tumor proliferation and metastasis.
In Vitro Studies
Use patient-derived cell lines to evaluate cytotoxic effects, determining IC50 values, and observing proliferation and apoptosis. Employ techniques like western blotting, flow cytometry, and microscopy to elucidate molecular interactions of compounds with their targets.
In Vivo Studies
Develop genetically engineered mouse models or xenograft models using human ovarian cancer tissues to closely mimic human disease. Evaluate ovarian cancer growth inhibition and regression when administering compounds, ensuring safety through histopathological examination of major organs.
With a commitment to exceptional expertise, the Alfa Cytology team delivers first-class service for sex cord-stromal tumors. Whatever your questions or needs, we welcome you contact us and are committed to answering your concerns.
Reference
- MAOZ A, MATSUO K, CICCONE M A, et al. Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord-Stromal Tumors: A Contemporary Review [J]. Cancers (Basel), 2020, 12(6).
! For research use only.
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