Ocular melanoma is a rare type of melanoma that arises from melanocytes in the uvea, conjunctiva, or eye orbits. And there's a 50% chance of a shift. Alfa Cytology is a world leader in the research of eye cancer. With our extensive experience and advanced platform, we can provide the best solutions for ocular melanoma.
Introduction to Ocular Melanoma
Ocular melanoma, the most common type of eye cancer, begins in the melanocytes of the eye and can affect vision and appearance. It accounts for approximately 3-5% of all melanoma cases. Ocular melanomas tend to spread hematogenously and usually involve the liver. Ocular melanoma may not cause signs and symptoms.
Fig.1 The site of ocular melanoma.
Common Therapy Development for Ocular Melanoma
The specific therapy options depend on the melanoma's location and size and the body's health. In general, traditional treatments include chemotherapy, radiation therapy, and surgery. With a deepening understanding, new therapy methods such as immunotherapy and targeted therapy have emerged in recent years. The effectiveness of immune checkpoint inhibitors and targeted therapy drugs in treating ocular melanoma is currently being studied.
- Immune Checkpoint Inhibitors: Drugs like pembrolizumab and nivolumab are being studied for their efficacy in treating ocular melanoma by boosting the immune system's response against cancer cells.
- Targeted Therapies: Agents targeting specific genetic mutations, such as selumetinib targeting the MEK pathway, are being investigated to inhibit the growth of ocular melanoma tumors.
In addition, melanoma-specific markers include HMB-45, tyrosinase, and MART-1/Melan-A, which can be used as specific targets for further study.
Our Services
For ocular melanoma, both traditional and new therapies have irreplaceable significance. Therefore, Alfa Cytology is working on providing one-stop solutions for ocular melanoma, including but not limited to the following.
Development Platforms
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Models of Ocular Melanoma
The ocular melanoma model is a key tool in uncovering the complexities of this rare but potentially deadly eye cancer. Alfa Cytology offers a range of models tailored to simulate the development and progression of ocular melanoma and species including mice, rats, zebrafish, chick, and non-human primates.
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Descriptions |
| Transplantable Models |
Transplantable models involve the ocular melanoma cells or tissue transplantation into experimental animals, enabling researchers to observe tumor progression and evaluate the efficacy of potential therapies. We offer the following options for transplantable models. |
- Heterotopic models
- Orthotopic models
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| Transgenic Models |
Transgenic models are genetically modified animals that simulate specific genetic alterations associated with ocular melanoma. These models are helpful to study the effects of targeted genetic mutations and explore the underlying disease mechanisms. |
Alfa Cytology is committed to the research and study of cancer, from molecular biology services, and cancer biomarker discovery services, to preclinical research services, providing one-stop services. Our cancer experts have many years of experience in the development of the latest therapies for ocular melanoma. If you are interested in our service, please contact us.
For research use only.
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