Spontaneous Tumor Model Development

Spontaneous prostate cancer modeling provides an important experimental tool for studying prostate cancer onset, progression, and therapy. Alfa Cytology is committed to providing our clients with a one-stop for spontaneous tumor model development, aiming to deliver reliable, reproducible, and translatable models that accurately accelerate the translational process from lab to therapy.

Introduction to Spontaneous Tumor Model

Spontaneous prostate cancer model is defined as the spontaneous generation of tumors in experimental animals under natural circumstances without any conscious artificial disposition. Canines can spontaneously generate prostate intraepithelial neoplastic hyperplasia (PIN) and prostate adenocarcinoma in animals, but are characterized by high age of occurrence, susceptibility to metastasis and late onset of androgen non-dependence. Moreover, canine experiments are more difficult to control, the spontaneous rate of cancer is lower, and the experiments are more expensive.

Fig.1 Widely used methods for generation of transgenic mice. (Onaciu, A., et al., 2020)

Variations in genetic predispositions across animal species result in diverse propensities for the development of spontaneous tumors. Models of spontaneity in oncogenesis are predominantly based on genetically engineered mice (GEMs) or other species that exhibit tumorigenesis as a consequence of inherent genetic alterations. Such models serve as a robust experimental framework for investigating the intricate interplay within the tumor microenvironment, the spectrum of genetic mutations, and the comprehensive progression of tumorigenesis.

Our Services

At Alfa Cytology, we utilize specialized platforms to develop our spontaneous prostate cancer models, ensuring that these models accurately map the clinical features of prostate cancer. From model preparation specifications to evaluation methods to safety assessments, we ensure that every step of the process follows strict international standards in order to provide a high standard of service.

Applications of Spontaneous Tumor Models

Alfa Cytology offers spontaneous tumor models that can be applied to a wide range of research topics, providing a powerful platform for advancing prostate cancer research.

At Alfa Cytology, we are committed to providing you with a comprehensive and efficient prostate cancer tumor model development service to support your research and drug development needs. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.