In Vivo Modeling Services for Bladder Cancer
In vivo models serve as powerful tools for studying bladder cancer due to their ability to recapitulate the complex tumor microenvironment, disease progression, and therapeutic responses observed in humans. At Alfa Cytology,we provide our clients with comprehensive in vivo modeling services for bladder cancer.
Introduction of In Vivo Models for Bladder Cancer
Bladder cancer is a prevalent malignancy that affects a significant number of individuals worldwide. It is crucial to develop effective therapy strategies and advance our understanding of this disease. In vivo modeling plays a critical role in bladder cancer research, allowing scientists to study the disease in a controlled environment that closely mimics the in vivo conditions.
In vivo models are shown below:
|
Types |
Description |
Syngeneic Models
- Mouse cells / tumor tissue in mice;
- Rat cells / tumor tissues in rats.
|
Subcutaneous injection / engraftment |
- Genetically engineered murine cell lines / primary cells
|
| Orthotopic engraftment |
- Primary urothelial or bladder cancer cells impaired in bladder wall of recipient host so that tumors arise in the bladder
|
| Spontaneous/Experimental metastasis |
- Spontaneous metastasis from primary site
- Intravenous (lV) injection of a bolus of tumor cells
|
Xenograft Models
- Human cells / tissues in immunocompromised mice.
|
Patients-derived tumors (PDX) |
- Potential as model individual tumors and subtypes
- Preclinical testing of specific therapeutics
- Tumor tissues are implanted in ectopic site
- Variable take rate depending on tumor subtype / phenotype
|
| Experimental metastasis |
- lV injection of a bolus of human tumor cells
- Genetically engineered human cell lines/primary cells
- Useful for studying organ tropism and later stages of metastasis
- Experimental therapeutics
|
Carcinogen-based Models
- Treatment of mice with carcinogen in drinking H2O most common is BBN.
|
- Recapitulates human disease with prolonged environmental exposure Useful (Diagnostic Biomarkers)
|
Genetically Engineered Models (GEMs)
- Expression of oncogenes and for tumor suppressors in the urothelium.
|
- Limited development of invasive and metastatic disease
- Conditional or inducible recombination of oncogenes or tumor suppressor genes in the urothelium
|
Our Services
At Alfa Cytology, we provide a wide range of in vivo modeling services tailored specifically for bladder cancer research. Our comprehensive services encompass every stage of the research process, from protocol design to project completion, ensuring that our clients receive the support they need to achieve their research goals efficiently. Here are some key aspects of our in vivo modeling services:
Contact Us
At Alfa Cytology, we are committed to providing exceptional in vivo modeling services for bladder cancer research. Our experienced team of scientists, state-of-the-art facilities, and extensive range of capabilities make us a preferred partner for researchers worldwide. Whether you require the development of PDX models, GEMMs, syngeneic models, or orthotopic models, we have the expertise and resources to meet your specific research needs.
To learn more about our in vivo modeling services for bladder cancer or to discuss your research project, please contact us today.
For research use only. Not intended for any clinical use.
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