Xenograft Ovarian Cancer Model Development

The development of the xenograft ovarian cancer model involves the implantation of human ovarian cancer cells into experimental animals, such as mice, to accurately mimic the growth and metastasis processes of human tumors. With extensive experience in developing these xenograft models, Alfa Cytology is dedicated to providing the cancer research community with an efficient and reliable experimental tool to facilitate the discovery and optimization of new therapies.

Introduction to Xenograft Ovarian Cancer Model

Xenograft models of ovarian cancer replicate human tumor growth by implanting cancer cell lines or patient-derived tissues into immunodeficient mice. These models, including cell line xenografts, orthotopic transplants, and stem cell models, accurately represent ovarian cancer's biological properties and host interactions. Researchers use these models for drug screening, therapeutic mechanism studies, and drug resistance analysis to elucidate tumor cell proliferation, metastasis, and treatment responses.

Fig.1 Construction of an ovarian cancer xenograft model. (KOMEN J, et al., 2021)

Applications of Xenograft Ovarian Cancer Model

This model is widely used in cancer research because it allows scientists to study the behavior of human cancer cells in a living organism, which closely mimics the tumor's environment.

• Targeted Therapy: Assessing the efficacy of drugs targeting specific molecular pathways in ovarian cancer cells.
• Resistance Mechanisms: Identifying mechanisms by which ovarian cancer cells develop resistance to chemotherapy and targeted therapies.
• Optimizing Dosing Regimens: Determining the most effective and safe dosing schedules for new therapeutic agents.

Our Services

Alfa Cytology boasts a multidisciplinary team of experts, including leading scientists in tumor biology, cell biology, and drug discovery. Leveraging extensive laboratory experience and state-of-the-art technology, Alfa Cytology is dedicated to developing highly efficient and reliable xenograft models that accurately mimic the biology of human ovarian cancer.

Subcutaneous Tumor Model

We established a subcutaneous ovarian cancer model by implanting human ovarian cancer cells or tissues into immunodeficient mice to mimic tumor growth.

• Pharmacodynamics Experiment
• Histochemical Analysis

CDX Mouse/Rat Model

The xenograft mouse/rat model (CDX model) of ovarian cancer replicates tumor growth by implanting human ovarian cancer cells into immunodeficient mice or rats.

• Immune Mechanism Research
• Transcriptomics Analysis

Disseminated Tumor Model

We simulate tumor metastasis by constructing a disseminated tumor model (DTM) through the injection of cancer cells into the bloodstream or peritoneal cavity.

• Analysis of Transfer Mechanisms
• Proteomic Analysis

Efficacy Evaluation in Xenograft Models

Alfa Cytology is capable of conducting xenograft studies on ovarian cancer to help clients gain insights into the disease's biology and potential therapies. By replicating human ovarian cancer growth and metastasis in immunodeficient mice, the study can support new drug development and efficacy evaluation. Should you have any questions or require further information regarding this study, please do not hesitate to contact us.

! For research use only.