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Molecular Glue Degrader Development Service
Molecular glue degraders (MGDs) refer to a class of compounds that facilitate interactions between two proteins or molecules within a cell. These compounds act as bridges to enhance specific protein-protein interactions (PPIs). Alfa Cytology is committed to providing a comprehensive one-stop MGDs development service.
Introduction to Molecular Glue Degraders
Molecular glue degraders (MGDs) are a novel class of small molecule drugs that enhance affinity between proteins, induce close proximity between target and effector proteins, and utilize cellular proteostasis mechanisms to promote degradation of target proteins. Currently, a number of development programs have been undertaken to develop innovative molecular glue degraders for prostate cancer. These trials may lead to new therapeutic options for prostate cancer treatment, especially for targets that are traditionally considered non-druggable.
Fig. 1 Molecular glues have been
developed for clinical indications (n = 13) and specific drug targets (n > 50). (Hemant Kumar, S., et al. 2024)
The distribution of targets for molecular glue compounds in various clinical indications provides insight into the current research and development landscape in this field. Among the identified indications, the largest number of targets for molecular glue compounds are in the field of oncology, with a focus on liquid tumors, including AML, leukemia, and myeloproliferative tumors (MPNs), as well as solid tumors.
Classification of Molecular Glue
Molecular glue (MG) is a small, monovalent molecule that induces proximity by either stabilizing natural protein interactions or inducing protein neomorphic interactions. Molecular glues can be further divided into three main categories: degradative molecular glues, non-degradative molecular glues or protein-interacting stabilizers, and molecular glues that induce self-association .
Degradative molecular glues are small molecules that promote the degradation of specific proteins by interacting with proteins and labeling them for recognition and degradation by the cell's
Non-degradable molecular glues are a class of small molecules that enhance or stabilize interactions between proteins. They function within cells by binding to specific regions of proteins and facilitating the formation of protein complexes.
Induced self-binding molecular glues are a class of small molecules capable of inducing interactions between different parts of the same protein or different protein molecules to form self-binding structures.
Our Services
At Alfa Cytology, our experts have been deeply involved in molecular glue degraders (MGDs) development in the field of prostate cancer for many years, and we have a professional team to provide you with 24-hour end-to-end development services to ensure that the entire development process is fast-tracked.
MGDs Discovery through AI
Providing artificial intelligence to rapidly screen large libraries of compounds and predict their interactions with target proteins and E3 ubiquitin ligases.
Expanding Degradable Proteome
Providing services to explore and validate new E3 ubiquitin ligases and substrate proteins, expanding the range of proteins that can be degraded by molecular glues.
Prioritizing E3 Ligases
Evaluating the role and importance of different E3 ubiquitin ligases in prostate cancer to determine which E3 ligases are the best targets for drug development.
Identifies Candidates
Services include in vitro and in vivo modeling studies of previously identified molecules to validate their degradative activity and potential therapeutic effects.
One-stop Solutions for Molecular Glue Degraders Development
Alfa Cytology provides one-stop Molecular glue degraders (MGDs) development services tailored specifically for prostate cancer.
If you are looking to develop innovative MGDs for prostate cancer, our expert team provide comprehensive support. Our mission is to advance prostate cancer therapy development by providing clients with efficient, innovative, and reliable solutions. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
Reference
- Hemant Kumar, S., et al. Advances in molecular glues: exploring chemical space and design principles for targeted protein degradation. Drug discovery today. 2024.
For research use only.