Adenocarcinoma is a relatively rare malignancy in the urinary bladder, which can originate primarily within the bladder or secondarily from various other organs. Alfa Cytology, as a leading global authority in bladder cancer research, leverages our extensive expertise and advanced platform to provide unparalleled research services for adenocarcinoma.

Introduction to Adenocarcinoma

Grossly, bladder adenocarcinoma typically originates from the trigone and posterior wall but can manifest in any region of the bladder. It commonly presents as a solitary lesion, in contrast to urothelial carcinoma which tends to be multifocal. Macroscopically, the tumor may exhibit papillary, sessile, solid, or ulcerating characteristics. The cut surface often displays a gelatinous appearance due to abundant mucin production.

Histologically, bladder adenocarcinoma exhibits various growth patterns.

• Enteric (colonic or intestinal) - The enteric pattern is composed of intestinal-type glands with pseudostratified columnar cells and nuclear atypia, closely resembling colorectal adenocarcinoma. It may produce intracellular or extracellular mucin, and necrosis is not infrequent.

Fig.1 Enteric-type bladder adenocarcinoma shows intestinal-type glands with columnar cells and marked cytologic atypia. (Dadhania, V., et al., 2015)

• Mucinous (colloid) - The mucinous pattern produces abundant extracellular mucin with tumor cells floating in a pool of mucin.

Fig.2 Mucinous-type bladder adenocarcinoma produces abundant extracellular mucin, forming a pool of mucin with floating tumor cells. (Dadhania, V., et al., 2015)

• Signet ring cell - The signet ring cell pattern is composed of diffusely infiltrative poorly differentiated cells with prominent intracellular mucin and indented eccentric nuclei. These tumors tend to present at an advanced stage and carry a worse prognosis than other variants.

Fig.3 Signet ring cell-type bladder adenocarcinoma is characterized by large intracellular mucin vacuoles that displace nuclei to the periphery. (Dadhania, V., et al., 2015)

• Not otherwise specified (NOS) - The NOS type has non-specific glandular growth.
• Mixed patterns - Tumors with more than one pattern are classified as the mixed type.

Therapy Development for Adenocarcinoma

The following is some therapies information regarding adenocarcinoma of the bladder cancer.

Our Services

Alfa Cytology offers a comprehensive range of research services tailored to address the complex pathophysiology of adenocarcinoma and facilitate the development of effective diagnostic and therapeutic strategies.

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Ongoing research and advancements in the understanding of adenocarcinoma biology continue to drive the development of innovative therapeutic approaches. At Alfa Cytology, we are dedicated to providing comprehensive and state-of-the-art solutions for adenocarcinoma therapy development. For further information regarding our extensive services, please do not hesitate to contact us.

• Muscle-Invasive Bladder Cancer
• Non-muscle Invasive Bladder Cancer
• Small Cell Carcinoma of the Bladder
• Squamous Cell Bladder Cancer
• Urothelial Carcinoma