Sequencing Services for Brain Tumors

With the rise of precision therapeutics and the widespread adoption of high-throughput gene sequencing technologies, gene sequencing has become a prevalent strategy in brain tumor research. Next-generation sequencing enables researchers to pinpoint individual gene alterations within brain tumors, offering valuable insights into therapeutic strategies. Alfa Cytology provides a range of cutting-edge sequencing technologies tailored to meet your diverse requirements.

Overview of Sequencing Services for Brain Tumors

With the popularity of powerful and high-throughput gene sequencing technologies, the practice of brain tumor sequencing has become increasingly crucial in elucidating the intricacies of genetic alterations and their diverse manifestations. Through sequencing, researchers can delve into brain tumor molecular typing, evaluate chemotherapy drug sensitivity and identify potential targets for tailored therapies. These capabilities highlight the importance of genomic mapping as a fundamental aspect of both diagnosing and predicting outcomes in brain tumors.

Fig.1 Single-cell RNA sequencing highlights transcriptomic heterogeneity in glioblastoma and glioblastoma stem cells. (Couturier CP., et al., 2020)

Our Services

With proficiency across various sequencing technologies, Alfa Cytology offers diverse omics analysis services for brain tumors to assist you in advancing diagnoses, personalized therapeutics, monitoring tumor recurrence and investigating potential drug resistance. Our expertise extends to testing samples from brain tumor tissue, blood and cerebrospinal fluid, ensuring a comprehensive approach to addressing your various needs.

Whole Genome Sequencing for Brain Tumors

The capacity of Whole Genome Sequencing (WGS) to offer a comprehensive perspective of the entire genome, coupled with our proficiency in managing extensive sample data, renders WGS a potent asset for fundamental brain tumor research. Our WGS services empower you to acquire deeper insights into the complexities of brain tumors.

Whole Exome Sequencing for Brain Tumors

Through Whole Exome Sequencing (WES), we provide a reliable method for genomic exploration of brain tumors, which effectively uncovers brain tumor susceptibility and pathogenicity genes. Our WES services assist researchers in pinpointing significant biomarkers of brain tumors that reflect therapeutic efficacy.

Targeted Sequencing for Brain Tumors

Targeted sequencing concentrates on specific genes of interest. With our targeted sequencing services, researchers can precisely identify mutations in brain tumor samples. Whether you focus on a select few genes or investigate a broader gene panel, our targeted sequencing approach provides enhanced sensitivity and specificity to support your brain tumor research.

Methylation Sequencing for Brain Tumors

Methylation sequencing services are offered to acquire methylation information and identify copy number variants in brain tumors. We support co-application with other techniques such as histology, making DNA methylation analysis an effective adjunct to brain tumor classification, especially for poorly characterized and rare brain tumor types and subtypes.

Single Cell Sequencing for Brain
Tumors

Single-cell sequencing technology represents a fresh view point for investigating brain tumor biology, aiding in the reidentification of genomic variants within brain tumor cells. This approach enables a deeper understanding of cellular states, gene expression regulation, transcriptional characteristics and the pathological processes involved in brain tumors.

Single Nucleus RNA Sequencing for Brain
Tumors

The snRNA-seq service provided involves the extraction of nuclei from various brain tumor tissues followed by high-throughput sequencing analysis of the transcriptome at the individual nucleus level. Through scrutinizing the gene expression status of individual nuclei, novel insights into heterogeneity among brain tumor cells can be revealed.

Why Choose Us?

Customized
Solutions

In-depth
Analysis

Strong
Expertise

Short
Turnaround

Through our brain tumor sequencing services, Alfa Cytology is dedicated to assisting researchers in identifying novel molecular biomarkers and delving into the underlying mechanisms of brain tumors, with the ultimate goal of developing personalized therapeutics. To initiate your project, please reach out to our staff for additional support and guidance.

Reference

Couturier CP.; et al. (2020). Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy[J]. Nature communications. 11(1), 3406.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.