Breast Cancer Animal Modeling Services
Breast cancer animal modeling uses animal models to study tumor biology, test therapies, and explore cancer behavior in a living organism. These models are crucial for understanding cancer progression, metastasis, and treatment responses. Alfa Cytology offers a comprehensive suite of breast cancer animal modeling services.
Introduction of Breast Cancer Animal Models
Breast cancer (BC) is the most prevalent malignancy among women. Animal models of BC exhibit significant similarities to human BC in terms of tumor etiology, biological behavior, pathology, and treatment response. Consequently, these models are indispensable in BC research. They serve as valuable tools for investigating BC biology, developing novel therapeutics, and predicting the safety and efficacy of candidate drugs in humans. This utility is crucial for advancing our understanding of BC progression, therapeutic responses, and mechanisms of drug resistance. Both spontaneous and induced BC models are primarily employed for etiological studies, prevention strategies, and post-treatment evaluations. Meanwhile, transplantation and genetically engineered models are currently the most widely utilized, contributing significantly to elucidating the mechanisms of drug resistance, BC pathogenesis, metastasis, drug efficacy, and toxicity assessment. Commonly used animal hosts for these models include mice, rats, and zebrafish.
Fig.1 Processing of tumor tissue as a single cell suspension, followed by subsequent implantation. (Singhal SS, et al., 2023)
Our Services
Alfa Cytology can provide you with an ideal and complete animal model. Our animal model is similar to the pathophysiological process of tumors in the human body, which is convenient for you to observe and monitor the efficacy of various treatments during the research process. At the same time, we can also provide you with pharmacological and toxicological animal experiment technical services.
| Models | Descriptions | Applications |
| Genetically engineered animal models of breast cancer | It is achieved through the artificial introduction of exogenous genes or specific DNA fragments into the genome of experimental animal models. | It can be applied to the research of BC pathogenesis, pathological mechanisms, and BC drug screening. |
| Spontaneous and induced animal tumor models | Spontaneous breast cancer (BC) tumors are those that arise naturally in animals or are maintained through genetic breeding. Induced BC tumors, on the other hand, refer to the experimental induction of breast cancer in animals using chemical substances, physical agents, or biological factors. | It can be applied to the etiology, treatment, prevention, evaluation of chemotherapy effects, and drug screening of BC. |
| Transplanted animal tumor models | Grafts utilized in engrafted breast cancer (BC) models originate from either spontaneous or induced breast tumor cell lines, as well as human BC cell lines. These grafts are established via the orthotopic or ectopic implantation of tumors into animals, employing techniques such as the injection of cancer cell suspensions and the inoculation of small tumor tissues. | It can be applied to BC drug screening, biomarkers discovery, tumor growth, and metastasis research. |
| Transplanted animal tumor models | Metastasis refers to the process wherein cancer cells disseminate from the primary tumor to other regions of the body. A metastasis model for breast cancer is designed to elucidate and forecast the patterns and mechanisms underlying breast cancer metastasis. | Metastasis models offer valuable insights into the mechanisms of breast cancer dissemination, the impact of various factors on metastatic behavior, and may assist in identifying novel therapeutic targets or treatment strategies. |
| PDX Models for Breast Cancer | Patient-Derived Xenograft (PDX) models for breast cancer are preclinical models that involve the direct implantation of tumor tissue from breast cancer patients into immunodeficient mice. These models are designed to replicate the characteristics and behavior of the original patient's tumor in a laboratory environment. | The capability to directly investigate patient-derived tumors within a living system offers a more clinically pertinent platform for the assessment of novel drugs, evaluation of therapeutic efficacy, and elucidation of tumor biology. |
Application Fields
- BC pathology
- BC treatment
- BC chemotherapy effect evaluation
- BC drug screening
- BC prevention
- BC biomarker discovery
Advantages of Our Services
- Scientific experimental animal selection
- Professional advice and guidance
- Strict quality control
- Rich project experience
Alfa Cytology offers customization of genetically engineered animal models, spontaneous and induced animal tumor models, as well as transplanted animal tumor models for BC. Establishing suitable animal models of BC is crucial for investigating the onset, progression, and metastasis of human BC. Leveraging our state-of-the-art platform and team of seasoned scientists, we can develop tailored, cost-effective, and reliable BC models to fulfill the specific needs of our global clientele. Should you be interested in our services, please do not hesitate to contact us; you will receive a prompt, professional, and precise response.
Reference
- Singhal SS, et al. Recent Advancement in Breast Cancer Research: Insights from Model Organisms-Mouse Models to Zebrafish. Cancers (Basel). 2023 May 29;15(11):2961.