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Breast cancer animal modeling uses animal models to study tumor biology, test therapies, and explore cancer behavior in a living organism. These models are crucial for understanding cancer progression, metastasis, and treatment responses. Alfa Cytology offers a comprehensive suite of breast cancer animal modeling services.
Breast cancer (BC) is the most common malignancy in women. Animal models of BC share much in common with human BC in terms of BC tumor etiology, biological behavior, pathology, and treatment response. Therefore, animal models play a very important role in BC research. Animal models can be used for BC biological research, new drug development, and can also predict the safety and effectiveness of candidate drugs in humans, which is helpful for the research of BC progression, therapeutic response, and drug resistance mechanism. Spontaneous and induced BC models are mainly used for the etiology, prevention, and post-treatment evaluation of BC. Transplantation and genetically engineered models are currently the most used, and they are widely used to elucidate the mechanism of drug resistance, BC pathogenesis and its metastasis, drug efficacy, and toxicity assessment. Commonly used animal model hosts include mice, rats, zebrafish, etc.
Fig.1 Processing of tumor tissue as a single cell suspension, followed by subsequent implantation. (Singhal SS, et al., 2023)
Alfa Cytology can provide you with an ideal and complete animal model. Our animal model is similar to the pathophysiological process of tumors in the human body, which is convenient for you to observe and monitor the efficacy of various treatments during the research process. At the same time, we can also provide you with pharmacological and toxicological animal experiment technical services.
| Models | Descriptions | Applications |
| Genetically engineered animal models of breast cancer | It is made by artificially introducing foreign genes or specific DNA fragments into the genome of experimental animal models. | It can be applied to the research of BC pathogenesis, pathological mechanisms, and BC drug screening. |
| Spontaneous and induced animal tumor models | Spontaneous BC tumors are tumors that occur naturally in animals or are preserved in genetic breeding. Induced BC tumor refers to the use of chemical substances, physical, biological factors, etc. to induce the occurrence of BC in experimental animals. | It can be applied to the etiology, treatment, prevention, evaluation of chemotherapy effects, and drug screening of BC. |
| Transplanted animal tumor models | Grafts used in engrafted BC models were derived from spontaneous or induced breast tumor cell lines or human BC cell lines. It is prepared by orthotopic or ectopic implantation of tumors into animals through methods such as cancer cell suspension injection and small tumor tissue inoculation. | It can be applied to BC drug screening, biomarkers discovery, tumor growth, and metastasis research. |
| Metastasis Model for Breast Cancer | Metastasis is the process by which cancer cells spread from the primary tumor to other parts of the body. A metastasis model for breast cancer aims to understand and predict the patterns and mechanisms of breast cancer metastasis. | Metastasis models can provide insights into how breast cancer spreads, how different factors influence metastatic behavior, and potentially help identify new therapeutic targets or treatment strategies. |
| PDX Models for Breast Cancer | PDX models for breast cancer are preclinical models that involve implanting tumor tissue from breast cancer patients directly into immunodeficient mice. These models aim to replicate the characteristics and behavior of the original patient's tumor in a laboratory setting. | The ability to directly study patient-derived tumors in a living system provides a more clinically relevant platform for testing new drugs, evaluating treatment efficacy, and understanding tumor biology. |
Alfa Cytology can customize BC genetically engineered animal models, spontaneous and induced animal tumor models, and transplanted animal tumor models for you. The establishment of appropriate animal models of BC plays an important role in the study of the occurrence, development, and metastasis of human BC. With our advanced platform and experienced scientists, we can build customized, cost-effective, and stable BC models to meet the specific requirements of global clients. If you are interested in our services, please contact us, and you will get a fast, professional, and accurate reply.
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