Basal cell carcinoma (BCC) is the most common type of skin cancer, accounting for about 75% of non-melanoma skin cancers, and develops from basal cells. Alfa Cytology is a world leader in the research of skin cancer. With our extensive experience and advanced platform, we can provide the best solutions for BCC.
Introduction to Basal Cell Carcinoma
With normal immune function, BCC's incidence rate is at least three times that of squamous cell carcinoma. BCC is composed of non-keratinized cells originating from the basal cell layer of the epidermis. Generally, it grows slowly and rarely metastasizes. BCC tends to have local destruction, and if left untreated or completely removed, it may lead to severe deformable damage. BCC usually has characteristic PTCH1 tumor suppressor gene mutations, but its carcinogenic mechanism is still unclear.
Fig.1 The incidence of BCC is related to sunlight exposure, including four stages. ( Kasakovski, D., et al., 2021)
Therapy Development for Basal Cell Carcinoma
There are various methods for treating BCC of the skin, including resection, radiation therapy, cryosurgery, electrolyzing and scraping, photodynamic or laser beam irradiation, and local therapy. The choice of method mainly depends on the stage or severity of the cancer. Still, other factors are also important, such as the overall health status and certain characteristics. However, local therapies cannot treat metastatic or locally advanced diseases. Here are the new therapies and pipelines.
| Targets |
Therapeutics |
Company |
Molecule Type |
Phase |
| Hedgehog pathway |
Vismodegib |
Genentech |
Small molecule |
|
| / |
VP-315 |
Verrica |
Oncolytic peptide |
|
Our Services
Basal cell skin cancer is unlikely to spread, but if it does, it usually directly enters the tissues and bones closest to the affected skin cancer area. Alfa Cytology is working on providing one-stop solutions for BCC, including but not limited to the following.
Therapeutic Development Platform
Cancer Modelling Platform
Preclinical Research Services
Models of Basal Cell Carcinoma
Models of BCC are used to study the biology of the disease, its progression, treatment response, and the development of new therapies. Alfa Cytology is a leading biological contract research organization (CRO). We have many years of experience in building BCC tumor models. Our company offers several popular BCC models, including but not limited to the following. Each model has its characteristics and applications.
Transgenic Models
- Ptch1 knockout mouse model
- SMO-mutated model
- K14-Shh transgenic mouse model
Alfa Cytology is committed to researching and studying skin cancer and provides one-stop services. Our cancer experts have many years of experience in the development of the latest therapies for basal cell carcinoma. For more information about our BCC research and development initiatives, or to inquire about our comprehensive services, please don't hesitate to contact us.
! For research use only.
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