Epigenetic modifications play an important role in prostate tumor development and progression. Alfa Cytology is committed to providing a comprehensive one-stop development service for epigenetic modulator development services in prostate cancer.
Epigenetic modifications, including DNA methylation patterns and post-translational modification of histone tails, have emerged as significant participants in PCa progression. In order to block or reverse epigenetic aberrations that promote cancer, much effort has been directed toward understanding epigenetic modifications that are possible to reverse.
Fig.
1 Graphic summary of epigenetic regulation in prostate cancer and potential therapeutic options. (Ge, R., et
al. 2020)
Significant advances have been made in targeted drug therapies for epigenetic regulation in prostate cancer.
Name | Target | Condition | Phase | Status |
Tazemetostat | EZH2 | mCRPC | Phase I | Recruiting |
Lirametostat | EZH2 | mCRPC | Phase I/II | Not yet recruiting |
PF-06821497 | EZH2 | CRPC | Phase I | Recruiting |
SHR2554 | EZH2 | CRPC | Phase I/II | Recruiting |
CC-90011 | LSD1 | mCRPC | Phase I | Terminated |
FT-7051 | P300/CBP | mCRPC | Phase I | Recruiting |
CCS1477 | P300/CBP | mCRPC | Phase I/II | Recruiting |
Birabiresib | BET bromodomain | CRPC | Phase I | Completed |
Mivebresib | BET bromodomain | PCa | Phase I | Completed |
Entibostat | HDACs | CRPC | Phase I | Terminated |
Pracinostat | HDACs | CRPC | Phase II | Completed |
Vorinostat | HDACs | Metastatic PCa | Phase II | Completed |
Decitabine | DNMT | PCa | Phase I/II | Withdraw |
Azacitidine | DNMT | PCa | Phase II | Completed |
At Alfa Cytology , our scientists have been deeply involved in epigenetic modulator development in prostate cancer for many years. And we have a professional team to provide you with 24-hour end-to-end development services to ensure that the entire epigenetic modulator development process is fast-tracked.
Small Molecule Inhibitors Development
Offering complete development of small molecule inhibitors, from discovering lead compounds to enhancing their chemistry, screening, and adjusting them for better performance.
Alfa Cytology offers a full range of services for therapies development targeted to epigenetic modulator in prostate cancer, including but not limited to the following.
The main epigenetic factors associated with prostate cancer are summarized below.
HMT | HAT | BET | HDAC | HDM | DNMT | TET |
EZH2 SUV39H1 SMYD3 PRMT5 NSD2 |
P300 CBP KAT2A KAT7 KAT8 |
BRD2 BRD3 BRD4 BRDT |
HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC7 SIRT1 SIRT2 |
KDM1A KDM3A KDM3B KDM4A KDM4B KDM5C KDM5D KDM6B KDM8 |
DNMT1 DNMT3A DNMT3B |
TET1 TET2 TET3 |
Our company is committed to providing customized one-stop services to accelerate your project development. With professional knowledge, we are committed to providing you with reliable experimental solutions, efficiently providing you with round-the-clock development services to ensure that your development is of low cost and confidentiality.
Qualified Experiment
Timely Delivery
Cost-Effective Services
Highly Confidential
At Alfa Cytology, our mission is to advance prostate cancer therapy development by providing a one-stop service for epigenetic modulator development. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
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