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Epigenetic Modulator Development

Epigenetic modifications play an important role in prostate tumor development and progression. Alfa Cytology is committed to providing a comprehensive one-stop development service for epigenetic modulator development services in prostate cancer.

Introduction to Epigenetic Modulator

Epigenetic modifications, including DNA methylation patterns and post-translational modification of histone tails, have emerged as significant participants in PCa progression. In order to block or reverse epigenetic aberrations that promote cancer, much effort has been directed toward understanding epigenetic modifications that are possible to reverse.

Fig. 1 Graphic summary of epigenetic regulation in prostate cancer and potential therapeutic options. (Ge, R., et al. 2020)Fig. 1 Graphic summary of epigenetic regulation in prostate cancer and potential therapeutic options. (Ge, R., et al. 2020)

Epigenetic Modulator Development for Prostate Cancer

Significant advances have been made in targeted drug therapies for epigenetic regulation in prostate cancer.

Name Target Condition Phase Status
Tazemetostat EZH2 mCRPC Phase I Recruiting
Lirametostat EZH2 mCRPC Phase I/II Not yet recruiting
PF-06821497 EZH2 CRPC Phase I Recruiting
SHR2554 EZH2 CRPC Phase I/II Recruiting
CC-90011 LSD1 mCRPC Phase I Terminated
FT-7051 P300/CBP mCRPC Phase I Recruiting
CCS1477 P300/CBP mCRPC Phase I/II Recruiting
Birabiresib BET bromodomain CRPC Phase I Completed
Mivebresib BET bromodomain PCa Phase I Completed
Entibostat HDACs CRPC Phase I Terminated
Pracinostat HDACs CRPC Phase II Completed
Vorinostat HDACs Metastatic PCa Phase II Completed
Decitabine DNMT PCa Phase I/II Withdraw
Azacitidine DNMT PCa Phase II Completed

Our Services

At Alfa Cytology , our scientists have been deeply involved in epigenetic modulator development in prostate cancer for many years. And we have a professional team to provide you with 24-hour end-to-end development services to ensure that the entire epigenetic modulator development process is fast-tracked.

Small Molecule Inhibitors Development

Offering complete development of small molecule inhibitors, from discovering lead compounds to enhancing their chemistry, screening, and adjusting them for better performance.

One-stop Solutions for Epigenetic Modulator Development

Alfa Cytology offers a full range of services for therapies development targeted to epigenetic modulator in prostate cancer, including but not limited to the following.

Epigenetic Factors Implicated in Prostate Cancer

The main epigenetic factors associated with prostate cancer are summarized below.

HMT HAT BET HDAC HDM DNMT TET
EZH2
SUV39H1
SMYD3
PRMT5
NSD2
P300
CBP
KAT2A
KAT7
KAT8
BRD2
BRD3
BRD4
BRDT
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC7
SIRT1
SIRT2
KDM1A
KDM3A
KDM3B
KDM4A
KDM4B
KDM5C
KDM5D
KDM6B
KDM8
DNMT1
DNMT3A
DNMT3B
TET1
TET2
TET3

Our Advantages

Our company is committed to providing customized one-stop services to accelerate your project development. With professional knowledge, we are committed to providing you with reliable experimental solutions, efficiently providing you with round-the-clock development services to ensure that your development is of low cost and confidentiality.

Qualified Experiment

Timely Delivery

Cost-Effective Services

Highly Confidential

At Alfa Cytology, our mission is to advance prostate cancer therapy development by providing a one-stop service for epigenetic modulator development. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.

Reference

  1. Ge, R., et al. Epigenetic modulations and lineage plasticity in advanced prostate cancer. Annals of oncology: official journal of the European Society for Medical Oncology. 2020, 31(4): 470–479.
notification For research use only.

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