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In Vivo Modeling Services for Prostate Cancer
Alfa Cytology specializes in providing comprehensive in vivo prostate cancer model development services aimed at supporting prostate cancer diagnosis and the development of novel therapeutic approaches through the creation and optimization of animal models that accurately mimic the biology of different prostate cancers.
Introduction to Prostate Cancer In Vivo Model
Prostate cancer in vivo models are disease models established in living animals to simulate the development of human prostate cancer. These models encompass a variety of types, such as tumor xenografts, patient-derived xenografts (PDX), and transgenic or knockout mouse models. These in vivo models provide an environment that closely mimics human physiology and pathology, making them indispensable for prostate cancer research and drug development.
Fig. 1 Schematic showing the generation of common preclinical murine cancer models. (Bareham, B., et al. 2021)
Our Services
At Alfa Cytology, with proven technology platforms and cutting-edge technology, our team offers comprehensive services for the development of existing, customized and novel models designed to deliver efficient, reproducible and validated in vivo prostate cancer models. Our comprehensive services cover every stage of the research process, from protocol design to project completion, ensuring that our clients receive the support they need to effectively achieve their research goals.
To bridge the gap in preclinical studies of prostate cancer, we offer humanized tumor models featuring immune system reconstitution and target humanization.
Provide customized genetic engineered models for customers, mainly including large fragment gene editing, CRISPR knock-out/knock-in and transgenic models.
Spontaneous tumor model development involves artificial gene editing methods, and the development also provides preclinical studies and screening for anti-tumor therapeutics.
Providing chemical induction model development services by feeding or intravenously injecting mice with specific chemical carcinogens.
To better assess the efficacy of cancer immunotherapy, we offer synthetic models that preserve the functional immune system. These models are useful for studying tumor-immune interactions.
By inoculating with commonly used cell lines such as PC-3, DU-145, LNCaP, C4-2, 22RV-1, Vcap, etc., we aim to provide a CDX model suitable for rapid in vivo testing of carcinogenicity and drug efficacy.
Through subcutaneous, subperitoneal, intravascular or intravascular inoculation, we offer PDX models, mainly involving CRPC, mCRPC and mCSPC models.
For different cell lines, we provide diverse inoculation strategies to construct stable, reliable and highly reproducible prostate cancer metastasis models, especially bone metastasis models.
Alfa Cytology offers sophisticated in vivo prostate cancer modeling services, propelling research and development forward with a comprehensive and state-of-the-art methodology. We guarantee that your research endeavors are equipped with superior, dependable In vivo prostate cancer models. If you are interested in our services, please don't hesitate to contact us for further information and pricing details.
Reference
- Bareham, B., et al. Modeling human tumor-immune environments in vivo for the preclinical assessment of immunotherapies. Cancer immunology, immunotherapy. 2021, 70(10): 2737-2750.
For research use only.